Publication Name	World Journal of Cardiology
Manuscript ID	91246
Country	United Kingdom

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Sodium glucose cotransporter-2 inhibitors and heart disease: Current perspectives
Manuscript Source	Invited Manuscript
All Author List	Sunetra Mondal, Subhodip Pramanik, Vibhu Ranjan Khare, Cornelius James Fernandez and Joseph M Pappachan
Funding Agency and Grant Number
Corresponding Author	Joseph M Pappachan, FRCP, MD, Academic Editor, Professor, Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust, Sharoe Green Lane, Preston PR2 9HT, United Kingdom. drpappachan@yahoo.co.in
Key Words	SGLT2 inhibitors; SGLT2i; Cardiovascular disease; Heart failure; Atherosclerotic cardiovascular disease; Diabetic kidney disease
Core Tip	The new antidiabetic medication class sodium glucose cotransporter-2 inhibitors (SGLT-2i) were found to have remarkable cardiovascular (CV) benefits proven by multiple randomised controlled trials and real-world observational studies. They are also useful in prevention of CV disease (CVD) in patients with diabetes mellitus. The CV benefits of SGLT-2i are not just because of antidiabetic effects. The preventive and management effects of SGLT2i molecules in diabetic and nondiabetic renal disease also translate into CV benefits. This clinical update review compiles the up-to-date evidence on the molecular mechanisms of SGLT-2i in prevention and management of CVD for empowering clinicians to rationalise the use of these molecules in day-to-day medical practice.
Citation	<p>Mondal S, Pramanik S, Khare VR, Fernandez CJ, Pappachan JM. Sodium glucose cotransporter-2 inhibitors and heart disease: Current perspectives. <i>World J Cardiol</i> 2024; 16(5): 240-259</p>

Received	2023-12-25 15:56
Peer-Review Started	2023-12-25 15:56
To Make the First Decision
Return for Revision	2024-04-08 06:09
Revised	2024-04-08 20:29
Second Decision	2024-04-28 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-04-28 08:29
Articles in Press	2024-04-28 08:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-14 08:20

ISSN	1949-8462 (online)
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