Publication Name	World Journal of Clinical Oncology
Manuscript ID	91347
Country	Russia

Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Different types of tumor microvessels in stage I-IIIA squamous cell lung cancer and their clinical significance
Manuscript Source	Invited Manuscript
All Author List	Marina A Senchukova, Evgeniy A Kalinin and Nadezhda N Volchenko
Funding Agency and Grant Number
Corresponding Author	Marina A Senchukova, MD, PhD, Professor, Department of Oncology, Orenburg State Medical University, Sovetskaya Street 6, Orenburg 460000, Russia. masenchukova@yandex.com
Key Words	Lung cancer; Lung squamous cell carcinoma; Tumor microvessels; Tumor stroma; Regional lymph node metastases; Disease recurrence; Disease prognosis
Core Tip	In this retrospective study, we examined the morphology of different types of tumor microvessels, tumor parenchyma, and tumor stroma and their associations with the risk of regional metastasis and disease recurrence in lung squamous cell carcinoma (LUSC) patients. Independent predictors of LUSC metastases in regional lymph nodes were the central location of the tumor (P < 0.00001), the presence of retraction clefts (P = 0.003), capillaries in the solid component of the tumor (P = 0.023) and fragmentation of the solid component of the tumor (P = 0.009), while independent predictors of LUSC recurrence were tumor grade 3 (P = 0.001), N2 stage (P = 0.016), the presence of loose fine fibrous connective tissue in the tumor stroma (P < 0.00001), fragmentation of the tumor solid component (P = 0.0001) and the absence of tumor spread through the alveolar air spaces (P = 0.0083). These findings may help improve the diagnosis and treatment of LUSC.
Citation	Senchukova MA, Kalinin EA, Volchenko NN. Different types of tumor microvessels in stage I-IIIA squamous cell lung cancer and their clinical significance. World J Clin Oncol 2024; In press

Received	2023-12-27 12:05
Peer-Review Started	2023-12-27 12:05
To Make the First Decision
Return for Revision	2024-01-17 02:43
Revised	2024-02-12 18:39
Second Decision	2024-03-28 01:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-28 05:58
Articles in Press	2024-03-28 05:58
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ISSN	2218-4333 (online)
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