Publication Name	World Journal of Experimental Medicine
Manuscript ID	91408
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Innovation in pathogenesis and management of aortic aneurysm
Manuscript Source	Invited Manuscript
All Author List	Maryam Barkhordarian, Hadrian Hoang-Vu Tran, Aiswarya Menon, Sai Priyanka Pulipaka, Izage Kianifar Aguilar, Axel Fuertes, Shraboni Dey, Angel Ann Chacko, Tanni Sethi, Ayrton Bangolo and Simcha Weissman
Funding Agency and Grant Number
Corresponding Author	Maryam Barkhordarian, MD, Doctor, Doctor, Department of Internal Medicine, Palisades Medical Center, 7600 River Road, North Bergen, NJ 07047, United States. marybarkhordar@gmail.com
Key Words	Aortic aneurysm; Abdominal aneurysm; Thoracic aneurysm; Immunotherapy; Surgical management; Pathophysiology; Inflammation and molecular pathways
Core Tip	This manuscript explores diverse pathophysiologic pathways (inflammation, atherosclerosis and immune system), varied treatment methods (pharmacological, radiation and surgical), and associated factors like inflammatory markers [transforming growth factor-β, interleukin (IL)-1β, tumor necrosis factor-, matrix metalloproteinase-2, IL-6, IL-8]. Genetic disorders linked to aortic aneurysms (AA) include Marfan syndrome, Ehler-Danlos syndrome, Loeys-Dietz syndrome, Cantu syndrome, and JAK-2 mutation. Approaches such as Low laser irradiation, photobiomodulation, UV-B irradiation may impact AA prevention and shrinkage. Medications like Canakinumab, Paricalcitol, peroxisome proliferator–activated receptor-γ agonist and mesenchymal stem cell transplantation are currently under investigation. Additionally, Different minimally invasive, endovascular surgical methods are highlighted.
Citation	<p>Barkhordarian M, Tran HHV, Menon A, Pulipaka SP, Aguilar IK, Fuertes A, Dey S, Chacko AA, Sethi T, Bangolo A, Weissman S. Innovation in pathogenesis and management of aortic aneurysm. <i>World J Exp Med</i> 2024; 14(2): 91408</p>

Received	2023-12-28 02:35
Peer-Review Started	2023-12-28 02:35
To Make the First Decision
Return for Revision	2024-01-16 08:25
Revised	2024-02-04 19:38
Second Decision	2024-03-18 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-03-18 08:28
Articles in Press	2024-03-18 08:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-06-11 02:23

ISSN	2220-315x (online)
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