Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	91468
Country	Serbia

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Neoadjuvant treatment of pancreatic ductal adenocarcinoma: Whom, when and how
Manuscript Source	Invited Manuscript
All Author List	Nebojsa Manojlovic, Goran Savic and Stevan Manojlovic
Funding Agency and Grant Number
Corresponding Author	Nebojsa Manojlovic, PhD, Associate Professor, Clinic for Gastroenterology and Hepatology, Military Medical Academy, Faculty of Medicine of the Military Medical Academy, University of Defence, Crnotravska 17, Belgrade 11000, Serbia. nebojsa.manojlovic1@gmail.com
Key Words	Pancreatic adenocarcinoma; Neoadjuvant treatment; Chemotherapy; Upfront surgery; Radiotherapy; Response evaluation
Core Tip	Pancreatic ductal adenocarcinoma, which is notorious for its aggressiveness and poor prognosis, remains an area of great unmet medical need. The most important determinant of survival is surgical resection. Nearly 60% of patients who undergo upfront surgery for resectable tumours are unable to receive adequate adjuvant chemotherapy (CHT). An important paradigm shift to achieve better outcomes has been the sequence of therapy, with neoadjuvant CHT preceding surgery. Three surgical stages have emerged for the preoperative assessment of nonmetastatic pancreatic cancers: Resectable, borderline-resectable and unresectable locally advanced tumours. In the development of new neoadjuvant and induction strategies, the distinct molecular and biological characteristics of the various pancreatic cancer subgroups need to be integrated to optimize the selection and sequencing of both established and novel treatment modalities that may improve survival outcomes.
Citation	Manojlovic N, Savic G, Manojlovic S. Neoadjuvant treatment of pancreatic ductal adenocarcinoma: Whom, when and how. World J Gastrointest Surg 2024; In press

Received	2023-12-28 23:34
Peer-Review Started	2023-12-28 23:34
To Make the First Decision
Return for Revision	2024-02-19 20:07
Revised	2024-03-13 16:03
Second Decision	2024-04-22 02:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-22 06:10
Articles in Press	2024-04-22 06:10
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ISSN	1948-9366 (online)
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