Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	91478
Country	Mexico

Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Assessing the impact of concurrent high-fructose and high-saturated fat diets on pediatric metabolic syndrome: A review
Manuscript Source	Invited Manuscript
All Author List	Manuel Alejandro Vargas-Vargas, Marcela González-Montoya, Olin Torres-Isidro, Claudia Isabel García-Berumen, Omar Ortiz-Avila, Elizabeth Calderón-Cortés and Christian Cortés-Rojo
Funding Agency and Grant Number	Funding Agency Grant Number Instituto de Ciencia, Tecnología e Innovación – Gobierno del Estado de Michoacán ICTI-PICIR23-063 Instituto de Ciencia, Tecnología e Innovación – Gobierno del Estado de Michoacán ICTI-PICIR23-028 Programa Proyectos de Investigación financiados 2024, Coordinación de Investigación Científica, Universidad Michoacana de San Nicolás de Hidalgo, México
Corresponding Author	Christian Cortés-Rojo, BSc, MSc, PhD, Professor, Instituto de Investigaciones Químico – Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-3, Ciudad Universitaria, Avenida Fco. J. Mujica, Morelia 58030, Michoacán, Mexico. christian.cortes@umich.mx
Key Words	Fructose; Saturated fat; Metabolic syndrome; Insulin resistance; Type 2 diabetes; Ultra processed foods; Children; Obesity; Dyslipidemia; Non-alcoholic fatty liver disease
Core Tip	High-fructose (HFr) or high-fat (HF) intake favors metabolic syndrome (MetS) development by different mechanisms. When combined, HFr exacerbates the effects of HF, leading to a faster and more severe MetS development. Combined HF + HFr is usually present in ultra-processed foods. However, there is a lack of studies in the pediatric population evaluating the impact of restricting the combined intake of carbohydrates and fat in MetS. We reviewed the mechanisms by which HF + HFr produces more severe MetS to support the need for studies targeting the combined intake of HF + HFr in pediatric population to improve the outcomes of different interventions against MetS.
Citation	Vargas-Vargas MA, González-Montoya M, Torres-Isidro O, García-Berumen CI, Ortiz-Avila O, Calderón-Cortés E, Cortés-Rojo C. Assessing the impact of concurrent high-fructose and high-saturated fat diets on pediatric metabolic syndrome: A review. World J Clin Pediatr 2024; In press

Received	2023-12-29 07:22
Peer-Review Started	2023-12-29 07:22
To Make the First Decision
Return for Revision	2024-04-09 04:38
Revised	2024-04-22 15:48
Second Decision	2024-05-06 02:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-05-06 10:23
Articles in Press	2024-05-06 10:23
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ISSN	2219-2808 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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