Publication Name	World Journal of Clinical Cases
Manuscript ID	91561
Country	India

Category	Endocrinology & Metabolism
Manuscript Type	Retrospective Cohort Study
Article Title	Prevalence and impact of diabetes and prediabetes on presentation and complications of primary hyperaldosteronism at diagnosis
Manuscript Source	Invited Manuscript
All Author List	Debmalya Sanyal, Pradip Mukhopadhyay and Sujoy Ghosh
Funding Agency and Grant Number
Corresponding Author	Debmalya Sanyal, FACE, Professor, Department of Endocrinology, NHRTIICS & KPC Medical College, 1F, Raja SC Mallick Road, Jadavpur, Kolkata 700032, West Bengal, India. drdebmalyasanyal@gmail.com
Key Words	Primary hyperaldosteronism; Diabetes; Prediabetes; Hypertension; Aldosterone; Aldosterone to renin ratio
Core Tip	Current investigation found a high prevalence of type 2 diabetes mellitus (T2DM) and prediabetes in primary hyperaldosteronism (PH) at diagnosis. However glycaemic status did not impact clinical or biochemical profiles, number of antihypertensive medications or complications. Long duration of hypertension, high antihypertensive requirement and hypokalemia with hypertension was the most common presentation, suggesting delayed PH diagnosis irrespective of glycaemic status. Underlying undetected PH can worsen hypertension, glycemia and cardiorenal risk in hypertensive patients with T2DM/prediabetes. Screening and early detection of PH in T2DM/prediabetes subjects with hypertension especially with hypokalemia or resistant hypertension, might help in effective management and preventing complications of hypertension and uncontrolled T2DM.
Citation	Sanyal D, Mukhopadhyay P, Ghosh S. Prevalence and impact of diabetes and prediabetes on presentation and complications of primary hyperaldosteronism at diagnosis. World J Clin Cases 2024; In press

Received	2023-12-30 16:20
Peer-Review Started	2023-12-30 16:20
To Make the First Decision
Return for Revision	2024-01-23 08:08
Revised	2024-02-06 05:54
Second Decision	2024-05-08 02:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-05-08 06:55
Articles in Press	2024-05-08 06:55
Publication Fee Transferred
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Typeset the Manuscript

ISSN	2307-8960 (online)
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