Publication Name	World Journal of Virology
Manuscript ID	91580
Country	Hungary

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Pathogenesis and clinical features of severe hepatitis E virus infection
Manuscript Source	Invited Manuscript
All Author List	László Orosz, Károly Péter Sárvári, Áron Dernovics, András Rosztóczy and Klára Megyeri
Funding Agency and Grant Number	Funding Agency Grant Number Interreg V-A Romania-Hungary Programme ROHU339
Corresponding Author	Klára Megyeri, MD, PhD, Associate Professor, Department of Medical Microbiology, University of Szeged, Dóm tér 10, Szeged 6720, Csongrád-Csanád, Hungary. megyeri.klara@med.u-szeged.hu
Key Words	Hepatitis E virus; Cirrhosis; Acute-on-chronic liver failure; Pregnancy; Immune dysfunction; Open reading frames 1-4
Core Tip	Hepatitis E virus (HEV) typically causes a self-limiting infection, but it can establish a persistent infection progressing into chronic hepatitis, cirrhosis or acute liver failure, particularly in individuals with compromised immune systems and preexisting liver diseases. In recent decades, the prevalence of hepatitis E has increased dramatically, and this trend continues unabated. Thus, a better understanding of the pathogenesis of hepatitis E and the development of more effective prevention and treatment strategies have become an urgent medical problem. We herein discuss the major features of HEV, the conditions predisposing to severe hepatitis E, and the underlying pathological immune processes.
Citation	Orosz L, Sárvári KP, Dernovics Á, Rosztóczy A, Megyeri K. Pathogenesis and clinical features of severe hepatitis E virus infection. World J Virol 2024; In press

Received	2023-12-31 08:29
Peer-Review Started	2023-12-31 08:29
To Make the First Decision
Return for Revision	2024-01-15 09:15
Revised	2024-02-08 18:55
Second Decision	2024-04-15 02:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-15 08:06
Articles in Press	2024-04-15 08:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3249 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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