Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	91629
Country	Mexico

Category	Oncology
Manuscript Type	Review
Article Title	Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression
Manuscript Source	Invited Manuscript
All Author List	Damián Sánchez-Ramírez, Mónica G Mendoza-Rodríguez, Omar R Alemán, Fernando A Candanedo-González, Miriam Rodríguez-Sosa, Juan José Montesinos-Montesinos, Mauricio Salcedo, Ismael Brito-Toledo, Felipe Vaca-Paniagua and Luis I Terrazas
Funding Agency and Grant Number	Funding Agency Grant Number Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica (PAPIIT) de la Dirección General de Asuntos de Personal Académico No. IN212722 and No. IA208424 Consejo Mexiquense de Ciencia y Tecnología No. CS000132 Consejo Nacional de Humanidades, Ciencia y Tecnología No. CF-2023-I- 563
Corresponding Author	Luis I Terrazas, PhD, Chairman, Senior Scientist, Unidad de Investigacion en Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, 1 Avenida de los Barrios, Tlalnepantla 54090, Estado de Mexico, Mexico. literrazas@unam.mx
Key Words	Cancer-associated fibroblasts; Signal transducer and activator of transcription signaling; Colorectal cancer; Immunity; Immunosuppression
Core Tip	The desmoplastic reaction (DR) is characterized by the excessive accumulation of connective tissue that encapsulates the tumor, made up of the recruitment of immune cells, activated fibroblasts, capillary formation, as well as the secretion of extracellular matrix proteins such as collagens, fibronectin, tenascin C, periostin, laminin, growth factors, cytokines, and chemokines. DR has been associated with the poor prognosis of patients and has been reported in various solid tumors: Ductal adenocarcinoma of the pancreas, breast cancer, lung cancer, ovarian cancer, head and neck cancer, colon cancer, colorectal cancer (CRC), among others. The cells responsible for the generation of DR are cancer-associated fibroblasts, and together, they promote tumor development by increasing proliferation, invasion, and migration of tumor cells, as well as resistance to chemotherapy and radiotherapy. In fact, the expression of stromal genes associated with DR has been reported to define a poor prognosis in CRC.
Citation	Sánchez-Ramírez D, Mendoza-Rodríguez MG, Alemán OR, Candanedo-González FA, Rodríguez-Sosa M, Montesinos-Montesinos JJ, Salcedo M, Brito-Toledo I, Vaca-Paniagua F, Terrazas LI. Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression. World J Gastrointest Oncol 2024; 16(5): 1705-1724

Received	2024-01-02 04:12
Peer-Review Started	2024-01-02 04:12
To Make the First Decision
Return for Revision	2024-02-02 20:46
Revised	2024-02-28 03:29
Second Decision	2024-04-01 06:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-01 08:27
Articles in Press	2024-04-01 08:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-23 01:50

ISSN	1948-5204 (online)
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