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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 91629
Country Mexico
Category Oncology
Manuscript Type Review
Article Title Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression
Manuscript Source Invited Manuscript
All Author List Damián Sánchez-Ramírez, Mónica G Mendoza-Rodríguez, Omar R Alemán, Fernando A Candanedo-González, Miriam Rodríguez-Sosa, Juan José Montesinos-Montesinos, Mauricio Salcedo, Ismael Brito-Toledo, Felipe Vaca-Paniagua and Luis I Terrazas
Funding Agency and Grant Number
Funding Agency Grant Number
Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica (PAPIIT) de la Dirección General de Asuntos de Personal Académico No. IN212722 and No. IA208424
Consejo Mexiquense de Ciencia y Tecnología No. CS000132
Consejo Nacional de Humanidades, Ciencia y Tecnología No. CF-2023-I- 563
Corresponding Author Luis I Terrazas, PhD, Chairman, Senior Scientist, Unidad de Investigacion en Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, 1 Avenida de los Barrios, Tlalnepantla 54090, Estado de Mexico, Mexico. literrazas@unam.mx
Key Words Cancer-associated fibroblasts; Signal transducer and activator of transcription signaling; Colorectal cancer; Immunity; Immunosuppression
Core Tip The desmoplastic reaction (DR) is characterized by the excessive accumulation of connective tissue that encapsulates the tumor, made up of the recruitment of immune cells, activated fibroblasts, capillary formation, as well as the secretion of extracellular matrix proteins such as collagens, fibronectin, tenascin C, periostin, laminin, growth factors, cytokines, and chemokines. DR has been associated with the poor prognosis of patients and has been reported in various solid tumors: Ductal adenocarcinoma of the pancreas, breast cancer, lung cancer, ovarian cancer, head and neck cancer, colon cancer, colorectal cancer (CRC), among others. The cells responsible for the generation of DR are cancer-associated fibroblasts, and together, they promote tumor development by increasing proliferation, invasion, and migration of tumor cells, as well as resistance to chemotherapy and radiotherapy. In fact, the expression of stromal genes associated with DR has been reported to define a poor prognosis in CRC.
Citation Sánchez-Ramírez D, Mendoza-Rodríguez MG, Alemán OR, Candanedo-González FA, Rodríguez-Sosa M, Montesinos-Montesinos JJ, Salcedo M, Brito-Toledo I, Vaca-Paniagua F, Terrazas LI. Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression. World J Gastrointest Oncol 2024; In press
Received
2024-01-02 04:12
Peer-Review Started
2024-01-02 04:12
To Make the First Decision
Return for Revision
2024-02-02 20:46
Revised
2024-02-28 03:29
Second Decision
2024-04-01 06:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-04-01 08:27
Articles in Press
2024-04-01 08:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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