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Publication Name World Journal of Clinical Oncology
Manuscript ID 91652
Country China
Category Oncology
Manuscript Type Retrospective Study
Article Title Human epidermal growth factor receptor 2 expression level and combined positive score can evaluate efficacy of advanced gastric cancer
Manuscript Source Unsolicited Manuscript
All Author List Xiao-Ting Ma, Kai Ou, Wen-Wei Yang, Bi-Yang Cao and Lin Yang
Funding Agency and Grant Number
Funding Agency Grant Number
Beijing CSCO Clinical Oncology Research Foundation No. Y-HH202102-0314
Corresponding Author Lin Yang, MD, Director, Doctor, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. linyangcicams@126.com
Key Words First line; Gastric cancer; Human epidermal growth factor receptor 2; Programmed cell death protein 1; Progression-free survival
Core Tip For when considering non-positive human epidermal growth factor receptor 2 (HER2) advanced gastric cancer (AGC), combined positive score and HER2 expression are represent influencing factors for the treatment efficacy of AGC patients receiving immunotherapy combined with chemotherapy. Survival analysis with When using progression-free survival (PFS) as the end point, survival analysis suggested that the HER2 expression level was levels are suggestive of the efficacy of treatment featuring a programmed cell death protein 1 inhibitor combined with and chemotherapy. With the increase of HER2 expression, PFS also showed a tendency to prolong increase with an increase in HER2 expression.
Citation Ma XT, Ou K, Yang WW, Cao BY, Yang L. Human epidermal growth factor receptor 2 expression level and combined positive score can evaluate efficacy of advanced gastric cancer. World J Clin Oncol 2024; In press
2024-01-02 16:17
Peer-Review Started
2024-01-02 16:17
To Make the First Decision
Return for Revision
2024-01-22 05:51
2024-02-08 21:38
Second Decision
2024-04-02 02:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-04-02 03:28
Articles in Press
2024-04-02 03:28
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ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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