Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	91750
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Metastatic stomach lymphoepithelioma-like carcinoma and immune checkpoint inhibitor therapy: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Guo-Feng Chen, Jun Wang, Yu Yan, Song Xu and Jian Chen
Funding Agency and Grant Number	Funding Agency Grant Number Zhejiang Provincial Key Project of Research and Development No. 2019C03043 National Natural Science Foundation of China No. 82203452 Health Science and Technology Plan of Zhejiang Province No. 2022RC165 Clinical Research Fund of Zhejiang Medical Association No. 2021ZYC-A68
Corresponding Author	Jian Chen, MD, PhD, Director, Department of Gastroenterology Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou 310000, Zhejiang Province, China. zrchenjian@zju.edu.cn
Key Words	Stomach neoplasm; Pulmonary lymphoepithelioma-like carcinoma; Metastasis; Immune checkpoint inhibitor; Case report
Core Tip	Pulmonary lymphoepithelioma-like carcinoma (PLELC) is a rare type of non-small-cell lung cancer. Stomach LELC metastasis secondary to PLELC has not been reported recently. We present a 64-year-old female patient who was admitted to our hospital for a regular gastroscopy examination with a 6-year history of surgical resection for left PLELC. After proximal gastrectomy, histopathological examination showed a poorly differentiated carcinoma with prominent lymphoplasmacytic infiltration, suggesting stomach LELC metastasis. Tumor programmed cell death ligand 1 (PD-L1) expression showed a tumor proportion score of 98% and a combined positive score of 100. After discharge, this patient underwent PD-1 inhibitor treatment for ten cycles and has not experienced tumor recurrence. These findings suggest that for gastric LELC metastasis, PD-1 inhibitor therapy could become a potential therapeutic approach.
Citation	Chen GF, Wang J, Yan Y, Xu S, Chen J. Metastatic stomach lymphoepithelioma-like carcinoma and immune checkpoint inhibitor therapy: A case report. World J Gastrointest Surg 2024; In press

Received	2024-01-04 07:18
Peer-Review Started	2024-01-04 07:18
To Make the First Decision
Return for Revision	2024-03-31 04:49
Revised	2024-04-10 07:43
Second Decision	2024-04-22 02:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-22 05:51
Articles in Press	2024-04-22 05:51
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ISSN	1948-9366 (online)
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