Publication Name	World Journal of Gastroenterology
Manuscript ID	91786
Country	Greece

Category	Oncology
Manuscript Type	Editorial
Article Title	Understanding autoimmune pancreatitis: Clinical features, management challenges, and association with malignancies
Manuscript Source	Invited Manuscript
All Author List	Grigorios Christodoulidis, Marina Nektaria Kouliou and Konstantinos Eleftherios Koumarelas
Funding Agency and Grant Number
Corresponding Author	Grigorios Christodoulidis, MD, PhD, Academic Editor, Department of General Surgery, University Hospital of Larissa, University of Thessaly, Biopolis Campus, Larissa 41110, Greece. gregsurg09@gmail.com
Key Words	Autoimmune pancreatitis; Immunoglobulin G4-related disease; Pancreatic cancer; Surgery
Core Tip	Autoimmune pancreatitis (AIP) is a unique form of pancreatitis, categorized into AIP-1 and AIP-2, with distinct clinical characteristics and associations. AIP-1, linked to elevated immunoglobulin G4 (IgG4) levels, exhibits higher relapse rates and predominantly affects older males, while AIP-2 is less common and associated with inflammatory bowel disease. Recognized as a manifestation of IgG4-related systemic disease, AIP poses an increased risk of malignancies, especially gastric, colorectal, and bladder cancers. Despite ongoing debates about the association with pancreatic cancer, careful diagnostic evaluation, including biopsy and response to steroids, is crucial for informed decision-making regarding surgery. AIP patients may have concurrent PanINs but generally experience better long-term outcomes compared to pancreatic cancer patients. Steroids remain the primary treatment, and emerging biomarkers like interferon alpha and interleukin-33 offer promising avenues for monitoring and managing AIP.
Citation	Christodoulidis G, Kouliou MN, Koumarelas KE. Understanding autoimmune pancreatitis: Clinical features, management challenges, and association with malignancies. World J Gastroenterol 2024; 30 (15)：2091-2095

Received	2024-01-05 09:42
Peer-Review Started	2024-01-05 09:42
To Make the First Decision
Return for Revision	2024-01-15 03:41
Revised	2024-01-24 16:39
Second Decision	2024-03-28 01:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-28 02:21
Articles in Press	2024-03-28 02:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-07 23:01

ISSN	1007-9327 (print) and 2219-2840 (online)
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