Publication Name	World Journal of Diabetes
Manuscript ID	91840
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Retrospective Cohort Study
Article Title	Evaluating new biomarkers for diabetic nephropathy: Role of α2-macroglobulin, podocalyxin, α-L-fucosidase, retinol-binding protein-4, and cystatin C
Manuscript Source	Unsolicited Manuscript
All Author List	Jing-Jing Li, Ru-La Sa, Yu Zhang and Zhao-Li Yan
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Inner Mongolia Autonomous Region No. 2022MS08057
Corresponding Author	Zhao-Li Yan, FAASLD, Chief Doctor, Research Fellow, Department of Endocrinology, The Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Road, Hohhot 010000, Inner Mongolia Autonomous Region, China. aliceyzl@126.com
Key Words	α2-macroglobulin; Podocalysin; α-L-fucosidase; Retinol binding protein-4; Cystatin C; Diabetic nephropathy
Core Tip	This study elucidates the diagnostic value of α2-macroglobulin (α2-MG), podocalyxin (PCX), α-L-fucosidase (AFU), retinol-binding protein-4 (RBP-4), and cystatin C (CysC) in type 2 diabetes mellitus and diabetic nephropathy (DN). It reveals that these biomarkers, especially urinary albumin to creatinine ratio (UACR), are strongly correlated with renal damage indicators. The research demonstrates the superior diagnostic capability of UACR for DN, while highlighting the importance of α2-MG, PCX, AFU, RBP-4, and CysC as complementary diagnostic tools. These findings provide valuable insights into the mechanisms of DN and enhance diagnostic accuracy in clinical practice.
Citation	Li JJ, Sa RL, Zhang Y, Yan ZL. Evaluating new biomarkers for diabetic nephropathy: Role of α2-macroglobulin, podocalyxin, α-L-fucosidase, retinol-binding protein-4, and cystatin C. World J Diabetes 2024; In press

Received	2024-01-09 09:13
Peer-Review Started	2024-01-07 06:14
To Make the First Decision
Return for Revision	2024-01-27 21:15
Revised	2024-02-27 08:37
Second Decision	2024-04-22 23:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-30 09:47
Articles in Press	2024-04-30 09:47
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Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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