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Publication Name World Journal of Clinical Cases
Manuscript ID 91878
Country China
Category Gastroenterology & Hepatology
Manuscript Type Clinical and Translational Research
Article Title Genetically predicted fatty liver disease and risk of psychiatric disorders: A mendelian randomization study
Manuscript Source Unsolicited Manuscript
All Author List Wei-Ming Xu, Hai-Fu Zhang, Yong-Hang Feng, Shuo-Jun Li and Bi-Yun Xie
Funding Agency and Grant Number
Corresponding Author Hai-Fu Zhang, MD, Doctor, Department of Internal Medicine, The First People's Hospital of Fuyang, No. 429 Beihuan Road, Fuchun Street, Hangzhou 311400, Zhejiang Province, China. 1375100541@qq.com
Key Words Non-alcoholic fatty liver disease; Alcohol-related liver disease; Psychiatric disorders; Mendelian randomization; Single nucleotide polymorphisms
Core Tip Non-alcoholic fatty liver disease and alcohol-related liver disease are the predominant forms of chronic liver diseases, with their incidence gradually increasing due to changing lifestyle habits. Observational studies have indicated a potential association between fatty liver and psychiatric disorders, necessitating Mendelian randomization studies to elucidate this relationship. The findings revealed significant associations between genetic susceptibility to hepatic steatosis and an elevated risk of a wide spectrum of psychiatric disorders, including bipolar disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. These results underscore the imperative for preventive measures targeting mental health conditions in individuals with fatty liver disease.
Citation Xu WM, Zhang HF, Feng YH, Li SJ, Xie BY. Genetically predicted fatty liver disease and risk of psychiatric disorders: A mendelian randomization study. World J Clin Cases 2024; In press
Received
2024-01-08 07:13
Peer-Review Started
2024-01-08 07:13
To Make the First Decision
Return for Revision
2024-02-06 04:27
Revised
2024-02-18 04:31
Second Decision
2024-04-02 02:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-04-02 06:49
Articles in Press
2024-04-02 06:49
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ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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