Publication Name	World Journal of Clinical Cases
Manuscript ID	91878
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical and Translational Research
Article Title	Genetically predicted fatty liver disease and risk of psychiatric disorders: A mendelian randomization study
Manuscript Source	Unsolicited Manuscript
All Author List	Wei-Ming Xu, Hai-Fu Zhang, Yong-Hang Feng, Shuo-Jun Li and Bi-Yun Xie
Funding Agency and Grant Number
Corresponding Author	Hai-Fu Zhang, MD, Doctor, Department of Internal Medicine, The First People's Hospital of Fuyang, No. 429 Beihuan Road, Fuchun Street, Hangzhou 311400, Zhejiang Province, China. 1375100541@qq.com
Key Words	Non-alcoholic fatty liver disease; Alcohol-related liver disease; Psychiatric disorders; Mendelian randomization; Single nucleotide polymorphisms
Core Tip	Non-alcoholic fatty liver disease and alcohol-related liver disease are the predominant forms of chronic liver diseases, with their incidence gradually increasing due to changing lifestyle habits. Observational studies have indicated a potential association between fatty liver and psychiatric disorders, necessitating Mendelian randomization studies to elucidate this relationship. The findings revealed significant associations between genetic susceptibility to hepatic steatosis and an elevated risk of a wide spectrum of psychiatric disorders, including bipolar disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. These results underscore the imperative for preventive measures targeting mental health conditions in individuals with fatty liver disease.
Citation	Xu WM, Zhang HF, Feng YH, Li SJ, Xie BY. Genetically predicted fatty liver disease and risk of psychiatric disorders: A mendelian randomization study. World J Clin Cases 2024; 12(14): 2359-2369

Received	2024-01-08 07:13
Peer-Review Started	2024-01-08 07:13
To Make the First Decision
Return for Revision	2024-02-06 04:27
Revised	2024-02-18 04:31
Second Decision	2024-04-02 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-04-02 06:49
Articles in Press	2024-04-02 06:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-24 10:57

ISSN	2307-8960 (online)
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