Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	92141
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Multi-Omics analysis elucidates tumor microenvironment and intratumor microbes of angiogenesis subtypes in colon cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Yi Yang, Yu-Ting Qiu, Wen-Kun Li, Zi-Lu Cui, Shuo Teng, Ya-Dan Wang and Jing Wu
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Science and Technology Program Z211100002921028 Capital’s Funds for Health Improvement and Research CFH2022-2-2025
Corresponding Author	Jing Wu, DO, MD, PhD, Dean, Doctor, Professor, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, No. 59 Yong’an Road, Xicheng District, Beijing 100050, China. wujing36youyi@ccmu.edu.cn
Key Words	Angiogenesis; Colon cancer; Immunotherapy; K-means; Single-cell analysis
Core Tip	Angiogenesis plays an important role in colon cancer (CC) progression. This study identified two angiogenesis subtypes (AGSs) with significantly different prognoses, tumor microenvironment, intratumor microbiota, drug sensitivity, and cancer-related pathways single-sample gene set enrichment analysis scores in patients with CC. Based on the two AGSs, a convenient 6-gene angiogenesis-related signature (ARS), was established to predict the prognosis in CC patients. SLC2A3 was selected as the representative gene of ARS, which was higher expressed in endothelial cells and promoted the migration of HUVECs.
Citation	Yang Y, Qiu YT, Li WK, Cui ZL, Teng S, Wang YD, Wu J. Multi-Omics analysis elucidates tumor microenvironment and intratumor microbes of angiogenesis subtypes in colon cancer. World J Gastrointest Oncol 2024; In press

Received	2024-01-19 07:29
Peer-Review Started	2024-01-19 07:29
To Make the First Decision
Return for Revision	2024-02-05 07:59
Revised	2024-02-13 11:26
Second Decision	2024-05-06 02:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-05-06 05:31
Articles in Press	2024-05-06 05:31
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Typeset the Manuscript

ISSN	1948-5204 (online)
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