Publication Name	World Journal of Hepatology
Manuscript ID	92330
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Diagnostic and prognostic role of LINC01767 in hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Li Zhang, Tong-Xing Cui, Xiang-Zhi Li, Chong Liu and Wen-Qin Wang
Funding Agency and Grant Number	Funding Agency Grant Number Foundation of Qingdao Postdoctoral Innovation Project QDBSH20230101019 Funded State Key Laboratory of Marine Food Processing & Safety Control, Qingdao SKL2023M05
Corresponding Author	Wen-Qin Wang, MMed, Postdoc, Researcher, School of Life Sciences, Shandong University (Qingdao), No. 72 of Binhai Road, Jimo District, Qingdao 26637, Shandong Province, China. wenqinwangsdu@163.com
Key Words	Hepatocellular carcinoma; LINC01767; Multi-omics analysis; GSE243371; Cell proliferation; Clone formation
Core Tip	LINC01767 was down-regulated based on The Cancer Genome Atlas and GSE dataset. It was positively with the cancer stemness in hepatocellular carcinoma (HCC) based on the single cell sequence data. LINC01767 demonstrate a good diagnostic and diagnostic performance. The 9-gene model demonstrated better performance than the 5-gene model in predicting the overall survival of HCC patients using least absolute shrinkage and selection operator regression, with an area under the curve greater than 0.75. LINC01767 was down regulated obviously in tumor than para-tumor tissues in our cohort. LINC01767 was down regulated in cancer cell line comparing with LO2; the over expression of LINC01767 inhibit the cell proliferation and imped the clone formation of Huh7 in vitro.
Citation	Zhang L, Cui TX, Li XZ, Liu C, Wang WQ. Diagnostic and prognostic role of LINC01767 in hepatocellular carcinoma. World J Hepatol 2024; In press

Received	2024-01-23 10:08
Peer-Review Started	2024-01-23 10:08
To Make the First Decision
Return for Revision	2024-03-12 04:24
Revised	2024-04-08 02:09
Second Decision	2024-04-28 02:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-28 08:01
Articles in Press	2024-04-28 08:01
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Typeset the Manuscript

ISSN	1948-5182 (online)
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