Publication Name	World Journal of Stem Cells
Manuscript ID	92363
Country	China

Category	Obstetrics & Gynecology
Manuscript Type	Basic Study
Article Title	Exosomes from umbilical cord mesenchymal stromal cells promote the collagen production of fibroblasts from pelvic organ prolapse
Manuscript Source	Unsolicited Manuscript
All Author List	Lei-Mei Xu, Xin-Xin Yu, Ning Zhang and Yi-Song Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81671439 Science and Technology Commission of Shanghai Municipality 21Y11906700, 20Y11907300 Medical Innovation Research Project of the Science and Technology Commission of Shanghai Municipality 22Y11906500
Corresponding Author	Yi-Song Chen, Doctor, Chief Doctor, Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, No. 128 Shenyang Road, Shanghai 200011, China. cys373900207@163.com
Key Words	Pelvic organ prolapse; Exosomes; Fibroblasts; Human umbilical cord mesenchymal stromal cells; Extracellular matrix; Collagen I
Core Tip	Our original article, titled “Exosomes derived from hucMSCs promote the growth and collagen production of fibroblasts from pelvic organ prolapse through microRNAs” focused on a promising cell-free treatment for pelvic organ prolapse (POP). Our study the first demonstrated that human umbilical cord mesenchymal stromal cell-derived exosome (hucMSC-Exo) at certain concentrations could facilitate the growth and extracellular matrix remodeling of the primary fibroblasts from POP. Morever, microRNA sequencing of hucMSC-Exos and high-throughput RNA sequencing of fibroblasts exposed to hucMSC-Exos revealed that highly expressed exosomal microRNAs targeted and downregulated the expression of matrix metalloproteinase 11 in fibroblasts, leading to the increased production of collagen I. These results suggested that hucMSC-Exos could be a promising treatment for POP and may overcome current therapeutic difficulties.
Citation	Xu LM, Yu XX, Zhang N, Chen YS. Exosomes from umbilical cord mesenchymal stromal cells promote the collagen production of fibroblasts from pelvic organ prolapse. World J Stem Cells 2024; In press

Received	2024-01-23 13:59
Peer-Review Started	2024-01-23 13:59
To Make the First Decision
Return for Revision	2024-03-09 06:15
Revised	2024-03-23 03:51
Second Decision	2024-04-15 10:05
Accepted by Journal Editor-in-Chief	2024-04-18 04:47
Accepted by Company Editor-in-Chief	2024-04-22 06:28
Articles in Press	2024-04-22 06:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com