Publication Name	World Journal of Hepatology
Manuscript ID	92426
Country	Germany

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Hepatitis E virus infection-triggered intrahepatic cholestasis: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Stephan Drexler, Frederic Haedge, Susanne N Weber, Marcin Krawczyk, Matthias S Matter, Carol I Geppert, Achim Weber, Bruno Stieger, Christian Trautwein and Andreas E Kremer
Funding Agency and Grant Number
Corresponding Author	Stephan Drexler, MD, Doctor, Department of Medicine III, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Aachen 52070, Germany. sdrexler@ukaachen.de
Key Words	Intrahepatic cholestasis; Hepatitis E; Next generation sequencing; ATP8B1; Case report
Core Tip	This case report highlights the role of genetic variations in hepatobiliary transporters in predisposing individuals to intrahepatic cholestasis and identifies hepatitis E virus (HEV) as a potential trigger. We present two cases of HEV-triggered intrahepatic cholestasis in patients with polymorphisms in ATP8B1 and other transporter genes. These findings suggest that these genetic variants may be susceptibility factors for cholestatic episodes, underscoring the need for further research to confirm these results in larger patient cohorts and through functional studies.
Citation	Drexler S, Haedge F, Weber SN, Krawczyk M, Matter MS, Geppert CI, Weber A, Stieger B, Trautwein C, Kremer AE. Hepatitis E virus infection-triggered intrahepatic cholestasis: A case report. World J Hepatol 2024; In press

Received	2024-01-25 14:43
Peer-Review Started	2024-01-26 00:52
To Make the First Decision
Return for Revision	2024-06-16 19:48
Revised	2024-06-30 07:03
Second Decision	2024-07-09 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-09 08:43
Articles in Press	2024-07-09 08:43
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Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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