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Publication Name World Journal of Hepatology
Manuscript ID 92426
Country Germany
Category Gastroenterology & Hepatology
Manuscript Type Case Report
Article Title Hepatitis E virus infection-triggered intrahepatic cholestasis: A case report
Manuscript Source Unsolicited Manuscript
All Author List Stephan Drexler, Frederic Haedge, Susanne N Weber, Marcin Krawczyk, Matthias S Matter, Carol I Geppert, Achim Weber, Bruno Stieger, Christian Trautwein and Andreas E Kremer
Funding Agency and Grant Number
Corresponding Author Stephan Drexler, MD, Doctor, Department of Medicine III, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Aachen 52070, Germany. sdrexler@ukaachen.de
Key Words Intrahepatic cholestasis; Hepatitis E; Next generation sequencing; ATP8B1; Case report
Core Tip This case report highlights the role of genetic variations in hepatobiliary transporters in predisposing individuals to intrahepatic cholestasis and identifies hepatitis E virus (HEV) as a potential trigger. We present two cases of HEV-triggered intrahepatic cholestasis in patients with polymorphisms in ATP8B1 and other transporter genes. These findings suggest that these genetic variants may be susceptibility factors for cholestatic episodes, underscoring the need for further research to confirm these results in larger patient cohorts and through functional studies.
Citation Drexler S, Haedge F, Weber SN, Krawczyk M, Matter MS, Geppert CI, Weber A, Stieger B, Trautwein C, Kremer AE. Hepatitis E virus infection-triggered intrahepatic cholestasis: A case report. World J Hepatol 2024; In press
2024-01-25 14:43
Peer-Review Started
2024-01-26 00:52
To Make the First Decision
Return for Revision
2024-06-16 19:48
2024-06-30 07:03
Second Decision
2024-07-09 02:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-07-09 08:43
Articles in Press
2024-07-09 08:43
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ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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