Publication Name	World Journal of Hepatology
Manuscript ID	92434
Country	China

Category	Genetics & Heredity
Manuscript Type	Case Report
Article Title	Successful treatment of severe hepatic impairment in erythropoietic protoporphyria: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Tao Zeng, Shu-Ru Chen, Hao-Qiang Liu, Yu-Tian Chong and Xin-Hua Li
Funding Agency and Grant Number
Corresponding Author	Xin-Hua Li, MD, PhD, Professor, Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Tianhe District, Guangzhou 510630, Guangdong Province, China. lixinh8@mail.sysu.edu.cn
Key Words	Erythropoietic protoporphyria; Red blood cell exchange; Plasma exchange; Delta-aminolevulinic acid; Ferrochelatase; Case report
Core Tip	Erythropoietic protoporphyria (EPP) is a rare autosomal recessive disorder, with few reported cases of associated hepatic injury, posing significant diagnostic challenges. Conventional therapies frequently fall short in severe cases, leading to the necessity for liver transplantation. Here, we report the case of a 35-year-old patient with EPP experiencing progressive liver dysfunction, unresponsive to standard medical care. A novel intervention comprising combined red blood cell exchange and plasma exchange therapies was administered. This approach resulted in a marked improvement in the patient’s liver function, highlighting a potentially effective alternative treatment for serious hepatic manifestations in EPP.
Citation	<p>Zeng T, Chen SR, Liu HQ, Chong YT, Li XH. Successful treatment of severe hepatic impairment in erythropoietic protoporphyria: A case report and review of literature. <i>World J Hepatol</i> 2024; 16(6): 966-972</p>

Received	2024-01-25 15:13
Peer-Review Started	2024-01-25 15:13
To Make the First Decision
Return for Revision	2024-04-29 20:00
Revised	2024-05-10 17:02
Second Decision	2024-05-14 02:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-05-14 03:50
Articles in Press	2024-05-14 03:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-05-31 08:54

ISSN	1948-5182 (online)
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