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Publication Name World Journal of Hepatology
Manuscript ID 92434
Country China
Category Genetics & Heredity
Manuscript Type Case Report
Article Title Successful treatment of severe hepatic impairment in erythropoietic protoporphyria: A case report and review of literature
Manuscript Source Unsolicited Manuscript
All Author List Tao Zeng, Shu-Ru Chen, Hao-Qiang Liu, Yu-Tian Chong and Xin-Hua Li
Funding Agency and Grant Number
Corresponding Author Xin-Hua Li, MD, PhD, Professor, Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Tianhe District, Guangzhou 510630, Guangdong Province, China. lixinh8@mail.sysu.edu.cn
Key Words Erythropoietic protoporphyria; Red blood cell exchange; Plasma exchange; Delta-aminolevulinic acid; Ferrochelatase; Case report
Core Tip Erythropoietic protoporphyria (EPP) is a rare autosomal recessive disorder, with few reported cases of associated hepatic injury, posing significant diagnostic challenges. Conventional therapies frequently fall short in severe cases, leading to the necessity for liver transplantation. Here, we report the case of a 35-year-old patient with EPP experiencing progressive liver dysfunction, unresponsive to standard medical care. A novel intervention comprising combined red blood cell exchange and plasma exchange therapies was administered. This approach resulted in a marked improvement in the patient’s liver function, highlighting a potentially effective alternative treatment for serious hepatic manifestations in EPP.
Citation Zeng T, Chen SR, Liu HQ, Chong YT, Li XH. Successful treatment of severe hepatic impairment in erythropoietic protoporphyria: A case report and review of literature. World J Hepatol 2024; In press
Received
2024-01-25 15:13
Peer-Review Started
2024-01-25 15:13
To Make the First Decision
Return for Revision
2024-04-29 20:00
Revised
2024-05-10 17:02
Second Decision
2024-05-14 02:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-05-14 03:50
Articles in Press
2024-05-14 03:50
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ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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