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Publication Name World Journal of Stem Cells
Manuscript ID 92457
Country China
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Umbilical cord mesenchymal stem cell exosomes alleviate necrotizing enterocolitis in neonatal mice by regulating intestinal epithelial cells autophagy
Manuscript Source Unsolicited Manuscript
All Author List Lin Zhu, Lu He, Wu Duan, Bo Yang and Ning Li
Funding Agency and Grant Number
Funding Agency Grant Number
China International Medical Foundation Z-2019-41-2101-04
China Postdoctoral Science Foundation Funded Project 2022M721957
West China Psychiatric Association WL2022102
Guangdong Basic and Applied Basic Research Foundation 2023A1515110717
Corresponding Author Ning Li, Doctor, Doctor, Department of Physical Education, Heze University, No. 2269 Daxue Road, Mudan District, Heze 274015, Shandong Province, China. hzlqlm@163.com
Key Words Necrotizing enterocolitis; Autophagy; Umbilical cord mesenchymal stem cell; Exosomes; Intestinal epithelial cell; Intestinal barrier function
Core Tip Based on observations of clinical samples, this study revealed a new mechanism by which human umbilical cord mesenchymal stem cells-derived exosomes reduce the inflammatory response and intestinal barrier dysfunction in neonatal mice with necrotizing enterocolitis (NEC) from the perspective of intestinal epithelial cell autophagy. These findings offer new insights for the clinical application of exosomes in NEC treatment and contribute to the establishment of a solid theoretical foundation.
Citation Zhu L, He L, Duan W, Yang B, Li N. Umbilical cord mesenchymal stem cell exosomes alleviate necrotizing enterocolitis in neonatal mice by regulating intestinal epithelial cells autophagy. World J Stem Cells 2024; In press
Received
2024-01-26 10:28
Peer-Review Started
2024-01-26 10:28
To Make the First Decision
Return for Revision
2024-03-12 03:53
Revised
2024-03-17 15:10
Second Decision
2024-04-15 10:04
Accepted by Journal Editor-in-Chief
2024-04-18 05:02
Accepted by Company Editor-in-Chief
2024-04-19 06:35
Articles in Press
2024-04-19 06:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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