Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	92468
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Neuroendocrine carcinoma of the common hepatic duct coexisting with distal cholangiocarcinoma: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Fei Chen, Wei-Wei Li, Juan-Fen Mo, Min-Jie Chen, Su-Hang Wang, Shu-Ying Yang and Zheng-Wei Song
Funding Agency and Grant Number	Funding Agency Grant Number Medical Health Science and Technology Project of Zhejiang Provincial Health Commission 2022KY1246 Science and Technology Bureau of Jiaxing City 2023AZ31002, 2022AZ10009
Corresponding Author	Zheng-Wei Song, Doctor, Doctor, Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Jiaxing University, No. 1518 Huanchen North Road, Jiaxing 314000, Zhejiang Province, China. doctorsongzw@163.com
Key Words	Neuroendocrine carcinoma; Mixed neuroendocrine-non-neuroendocrine neoplasm; Cholangiocarcinoma; Extrahepatic bile duct; Case report
Core Tip	We reported a rare case of primary large cell neuroendocrine carcinoma (NEC) of the hepatic duct combined with distal cholangiocarcinoma (dCCA). The overall survival was 24 months, and the prognosis was relatively good, which may be related to the early stage and low Ki-67 index of NEC and the early stage and moderate differentiation of the coexisting dCCA. To explore genetic causes, gene sequencing was performed on the two types of cancer tissue. A total of 35 gene mutations were detected in NEC tissue, and 7 gene mutations were detected in adenocarcinoma tissue.
Citation	Chen F, Li WW, Mo JF, Chen MJ, Wang SH, Yang SY, Song ZW. Neuroendocrine carcinoma of the common hepatic duct coexisting with distal cholangiocarcinoma: A case report and review of literature. World J Gastrointest Surg 2024; In press

Received	2024-01-27 04:30
Peer-Review Started	2024-01-27 04:30
To Make the First Decision
Return for Revision	2024-03-01 13:10
Revised	2024-03-13 15:51
Second Decision	2024-04-15 02:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-15 05:44
Articles in Press	2024-04-15 05:44
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Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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