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4/2/2024 3:10:32 AM | Browse: 44 | Download: 0
Publication Name World Journal of Stem Cells
Manuscript ID 92572
Country China
Category Pharmacology & Pharmacy
Manuscript Type Basic Study
Article Title Effect of ginsenoside Rg1 on hematopoietic stem cells in treating aplastic anemia in mice via MAPK pathway
Manuscript Source Unsolicited Manuscript
All Author List Jin-Bo Wang, Ming-Wei Du and Yan Zheng
Funding Agency and Grant Number
Funding Agency Grant Number
Hangzhou Municipal Bureau of Science and Technology 2021WJCY366
Corresponding Author Yan Zheng, MMed, Staff Physician, Department of Hepatic, The Xixi Hospital of Hangzhou Affiliated to Zhejiang University of Traditional Chinese Medicine, No. 2 Hengbu Street, Liuliu Town, Xihu District, Hangzhou 310023, Zhejiang Province, China. zjhzzygood@163.com
Key Words Aplastic anemia; Ginsenoside Rg1; Myelosuppression; MAPK signaling pathway; Bone marrow; Hematopoietic stem cells
Core Tip This study evaluates ginsenoside Rg1’s efficacy in aplastic anemia (AA) treatment, focusing on its impact on bone marrow pathology, hematopoiesis, and inflammation in a cyclophosphamide-induced myelosuppression C57 mice model. It demonstrates that ginsenoside Rg1 not only reduces cell apoptosis and inflammation but also promotes hematopoietic recovery by inhibiting the MAPK signaling pathway, offering a potential therapeutic strategy for AA.
Citation Wang JB, Du MW, Zheng Y. Effect of ginsenoside Rg1 on hematopoietic stem cells in treating aplastic anemia in mice via MAPK pathway. World J Stem Cells 2024; In press
Received
2024-01-30 04:03
Peer-Review Started
2024-01-30 04:03
To Make the First Decision
Return for Revision
2024-02-07 06:16
Revised
2024-02-20 08:17
Second Decision
2024-03-21 02:51
Accepted by Journal Editor-in-Chief
2024-03-24 05:47
Accepted by Company Editor-in-Chief
2024-04-02 03:10
Articles in Press
2024-04-02 03:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
2024-04-06 22:59
Typeset the Manuscript
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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