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Publication Name World Journal of Experimental Medicine
Manuscript ID 92589
Country Sweden
Category Endocrinology & Metabolism
Manuscript Type Basic Study
Article Title Amylase intrapancreatic infusion delays insulin release during an intravenous glucose tolerance test, proof of acini-islet-acinar interactions
Manuscript Source Unsolicited Manuscript
All Author List Kateryna Pierzynowska, Piotr Wychowanski, Kamil Zaworski, Jarosław Woliński, Janine Donaldson, Dominika Szkopek, Katarzyna Roszkowicz-Ostrowska, Agata Kondej and Stefan G Pierzynowski
Funding Agency and Grant Number
Corresponding Author Kateryna Pierzynowska, DSc, PhD, Associate Professor, Senior Research Fellow, Department of Biology, Lund University, Sölvegatan 35, Lund 22362, Sweden. kateryna.pierzynowska@biol.lu.se
Key Words Amylase; Glucose-insulin-amylase interaction; Intravenous glucose tolerance test; Acini-islet-acinar axis; Insulin
Core Tip The acini-islet-acinar axis involves the inhibition of insulin production by amylase and the stimulation of amylase release by insulin, which is of particular significance with regards to glucose regulation. There is increasing evidence that amylase levels correspond to overall metabolic health, with low amylase levels being significantly associated with the development of metabolic syndrome, diabetes, and obesity. Disruption of the highly integrated glucose-insulin interactions by intrapancreatic arterial amylase infusion in the present study confirms the existence of an AIA reflex and justifies the placement of the exocrine and endocrine pancreatic components within the same organ.
Citation Pierzynowska K, Wychowański P, Zaworski K, Woliński J, Donaldson J, Szkopek D, Roszkowicz-Ostrowska K, Kondej A, Pierzynowski SG. Amylase intrapancreatic infusion delays insulin release during an intravenous glucose tolerance test, proof of acini-islet-acinar interactions. World J Exp Med 2024; In press
Received
2024-01-31 13:27
Peer-Review Started
2024-01-31 13:27
To Make the First Decision
Return for Revision
2024-06-07 19:50
Revised
2024-06-19 11:40
Second Decision
2024-07-09 02:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-07-10 08:44
Articles in Press
2024-07-10 08:44
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ISSN 2220-315x (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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