Publication Name	World Journal of Experimental Medicine
Manuscript ID	92589
Country	Sweden

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Amylase intrapancreatic infusion delays insulin release during an intravenous glucose tolerance test, proof of acini-islet-acinar interactions
Manuscript Source	Unsolicited Manuscript
All Author List	Kateryna Pierzynowska, Piotr Wychowanski, Kamil Zaworski, Jarosław Woliński, Janine Donaldson, Dominika Szkopek, Katarzyna Roszkowicz-Ostrowska, Agata Kondej and Stefan G Pierzynowski
Funding Agency and Grant Number
Corresponding Author	Kateryna Pierzynowska, DSc, PhD, Associate Professor, Senior Research Fellow, Department of Biology, Lund University, Sölvegatan 35, Lund 22362, Sweden. kateryna.pierzynowska@biol.lu.se
Key Words	Amylase; Glucose-insulin-amylase interaction; Intravenous glucose tolerance test; Acini-islet-acinar axis; Insulin
Core Tip	The acini-islet-acinar axis involves the inhibition of insulin production by amylase and the stimulation of amylase release by insulin, which is of particular significance with regards to glucose regulation. There is increasing evidence that amylase levels correspond to overall metabolic health, with low amylase levels being significantly associated with the development of metabolic syndrome, diabetes, and obesity. Disruption of the highly integrated glucose-insulin interactions by intrapancreatic arterial amylase infusion in the present study confirms the existence of an AIA reflex and justifies the placement of the exocrine and endocrine pancreatic components within the same organ.
Citation	<p>Pierzynowska K, Wychowanski P, Zaworski K, Woliński J, Donaldson J, Szkopek D, Roszkowicz-Ostrowska K, Kondej A, Pierzynowski SG. Amylase intrapancreatic infusion delays insulin release during an intravenous glucose tolerance test, proof of acini-islet-acinar interactions. <i>World J Exp Med</i> 2024; 14(3): 92589</p>

Received	2024-01-31 13:27
Peer-Review Started	2024-01-31 13:27
To Make the First Decision
Return for Revision	2024-06-07 19:50
Revised	2024-06-19 11:40
Second Decision	2024-07-09 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-10 08:44
Articles in Press	2024-07-10 08:44
Publication Fee Transferred	2024-07-31 07:28
Edit the Manuscript by Language Editor	2024-08-14 16:10
Typeset the Manuscript	2024-08-22 03:56

ISSN	2220-315x (online)
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