Publication Name	World Journal of Hepatology
Manuscript ID	92684
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Quantifying the natural growth rate of hepatocellular carcinoma: A real-world retrospective study in southwestern China
Manuscript Source	Unsolicited Manuscript
All Author List	Li Tu, Hong Xie, Qi Li, Ping-Gui Lei, Pei-Ling Zhao, Fan Yang, Chi Gong, Yuan-Lin Yao and Shi Zhou
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81960328 Cultivate Project for the National Natural Science Foundation of China gyfynsfc[2020]-27
Corresponding Author	Hong Xie, Doctor, Professor, Clinical Medicine, Soochow University, No. 199 Renai Road, Suzhou 215123, Jiangsu Province, China. doctorxie2007@yeah.net
Key Words	Hepatocellular carcinoma; Natural tumor growth pattern; Tumor volume doubling time; Tumor growth rate; Real-world retrospective study
Core Tip	The present study offers real-world data, revealing a median tumor volume doubling time of 163 d for hepatocellular carcinoma (HCC) patients in Southwest China. These findings endorse the implementation of biannual surveillance and follow-up for this patient population. The observed heterogeneity in HCC growth, with approximately one-third of patients exhibiting indolent, intermediate, or rapid growth, highlights the necessity for individualized management and targeted treatment strategies based on specific tumor growth rate. Further research is essential to elucidate the mechanisms driving this growth heterogeneity and to inform clinical practice.
Citation	Tu L, Xie H, Li Q, Lei PG, Zhao PL, Yang F, Gong C, Yao YL, Zhou S. Quantifying the natural growth rate of hepatocellular carcinoma: A real-world retrospective study in southwestern China. World J Hepatol 2024; In press

Received	2024-02-08 14:29
Peer-Review Started	2024-02-08 14:29
To Make the First Decision
Return for Revision	2024-03-02 07:02
Revised	2024-04-10 15:44
Second Decision	2024-04-18 02:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-18 05:51
Articles in Press	2024-04-18 05:51
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Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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