Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	92737
Country	Egypt

Category	Developmental Biology
Manuscript Type	Systematic Reviews
Article Title	Metabolomic changes in children with autism
Manuscript Source	Invited Manuscript
All Author List	Mohammed Al-Beltagi, Nermin Kamal Saeed, Adel Salah Bediwy and Reem Elbeltagi
Funding Agency and Grant Number
Corresponding Author	Mohammed Al-Beltagi, MBChB, MD, PhD, Academic Editor, Chairman, Professor, Research Scientist, Department of Pediatric , Faculty of Medicine, Tanta University, Al-Bahr Street, The Medical Complex, Tanta ‎ 31511‎, Alghrabia, Egypt. mbelrem@hotmail.com
Key Words	Autism spectrum disorder; Metabolic dysregulations; Metabolomic changes; ‎Children; Mitochondrial dysfunction; Oxidative stress; Amino acids
Core Tip	This systematic review examines metabolic changes in individuals with autism spectrum disorder (ASD) by integrating various sources of evidence. Through an extensive search, the review explores factors influencing metabolomic changes in children with ASD, such as age, genetics, diet, gut microbiota, and medical interventions. The systematic review identifies common metabolic dysregulations, including abnormalities in energy metabolism, oxidative stress, mitochondrial dysfunction, and neurotransmitter metabolism. Despite limitations, integrating metabolomic changes in ASD holds promise for improving diagnosis and treatment approaches.
Citation	Al-Beltagi M, Saeed NK, Bediwy AS, Elbeltagi R. Metabolomic changes in children with autism. World J Clin Pediatr 2024; In press

Received	2024-02-04 10:32
Peer-Review Started	2024-02-04 10:32
To Make the First Decision
Return for Revision	2024-04-19 05:54
Revised	2024-04-23 17:54
Second Decision	2024-05-06 02:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-05-06 10:28
Articles in Press	2024-05-06 10:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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