Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	92791
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Metabolic dysfunction-associated steatotic liver disease heterogeneity: Need of subtyping
Manuscript Source	Unsolicited Manuscript
All Author List	Shahid Habib
Funding Agency and Grant Number
Corresponding Author	Shahid Habib, MD, Doctor, Researcher, Department of Hepatology, Liver Institute PLLC, 3232 E Speedway Bvd, Tucson, AZ 85718, United States. shabib@liverinstitutepllc.org
Key Words	Metabolic dysfunctions-associated steatotic liver disease; Visceral obesity; Genetics; Diabetes; Insulin resistance
Core Tip	Metabolic dysfunctions-associated steatotic liver disease (MASLD) is a pathogenically heterogeneous disease with dynamic pathological features. The cardiometabolic risk of MASLD varies based on underlying etiopathogenic processes. Four subtypes of MASLD have been identified: Diabetic, non-diabetic (insulin resistance), genetic and mixed. These subtypes have not been clearly defined yet as separate entities. Given such heterogeneity, the behavior and outcome of MASLD in each patient is expected to be different. Therefore, a single drug is not expected to work for all patients with MASLD. The natural history of MASLD subtypes is unknown. There is an unmet need to categorize its subtypes and prospective studies are needed to characterize each subtype.
Citation	Habib S. Metabolic dysfunction-associated steatotic liver disease heterogeneity: Need of subtyping. World J Gastrointest Pathophysiol 2024; In press

Received	2024-02-05 18:42
Peer-Review Started	2024-02-05 18:42
To Make the First Decision
Return for Revision	2024-03-05 04:49
Revised	2024-04-04 05:39
Second Decision	2024-04-24 02:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-24 09:40
Articles in Press	2024-04-24 09:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5330 (online)
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