| Category |
Integrative & Complementary Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Weiwei Decoction alleviates gastric intestinal metaplasia through the olfactomedin 4/nucleotide-binding oligomerization domain 1/caudal-type homeobox gene 2 signaling pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Di-Shu Zhou, Wei-Jian Zhang, Shu-Ya Song, Xin-Xin Hong, Wei-Qin Yang, Juan-Juan Li, Jian-Qu Xu, Jian-Yuan Kang, Tian-Tian Cai, Yi-Fei Xu, Shao-Ju Guo, Hua-Feng Pan and Hai-Wen Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82104747, 82305133 |
| Basic and Applied Basic Research Foundation of Guangdong Province, China |
2020A1515110947 |
| General Project of Shenzhen Science and Innovation Commission |
JCYJ20230807094659030, JCYJ20230807094805012 |
| General Project of Shenzhen Science and Innovation Commission |
JCYJ20210324111602007, JCYJ20220531091815034 |
| Scientific Research Project of Guangdong Bureau of Traditional Chinese Medicine |
20221349 |
|
| Corresponding Author |
Hai-Wen Li, MD, Attending Doctor, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, No. 1 Fuhua Road, Futian District, Shenzhen 518033, Guangdong Province, China. 370062941@qq.com |
| Key Words |
Gastric intestinal metaplasia; Weiwei Decoction; Olfactomedin 4; Nucleotide-binding oligomerization domain 1; Caudal-type homeobox gene 2; Gastric cancer |
| Core Tip |
Gastric intestinal metaplasia (IM) is a precancerous lesion that is associated with an elevated risk of gastric carcinogenesis. Weiwei Decoction (WWD) is a traditional Chinese herbal formula derived from Sijunzi Decoction that has been utilized to treat gastric disease for thousands of years. Nowadays, WWD is widely employed in clinical for treating IM. Previous studies suggested the potential involvement of the olfactomedin 4 (OLFM4)/nucleotide-binding oligomerization domain 1 (NOD1)/caudal-type homeobox gene 2 (CDX2) pathway in IM regulation. In this study, we preliminarily validated the pivotal role of the OLFM4/NOD1/CDX2 signaling pathway in regulating gastric IM. Focusing on this pathway, our investigation centered on the therapeutic effects of WWD against gastric IM. |
| Citation |
Zhou DS, Zhang WJ, Song SY, Hong XX, Yang WQ, Li JJ, Xu JQ, Kang JY, Cai TT, Xu YF, Guo SJ, Pan HF, Li HW. Weiwei Decoction alleviates gastric intestinal metaplasia through the olfactomedin 4/nucleotide-binding oligomerization domain 1/caudal-type homeobox gene 2 signaling pathway. World J Gastrointest Oncol 2024; In press |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
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|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
