Publication Name	World Journal of Hepatology
Manuscript ID	93028
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Nano-revolution in hepatocellular carcinoma: A multidisciplinary odyssey - Are we there yet?
Manuscript Source	Invited Manuscript
All Author List	Howard D Lee and Li-Yun Yuan
Funding Agency and Grant Number
Corresponding Author	Howard D Lee, MD, Academic Fellow, Doctor, Department of Medicine, Division of Gastrointestinal and Liver Diseases, Keck School of Medicine of University of Southern California, 1975 Zonal Ave, Los Angeles, CA 90033, United States. howard.lee@med.usc.edu
Key Words	Hepatocellular carcinoma; Nanomedicine; Ligand-receptor mediated nanotherapy; Precision medicine; Personalized medicine; Targeting
Core Tip	Despite recent advances in locoregional and systemic therapy for the treatment of hepatocellular carcinoma, current conventional treatment of advanced disease only offers limited survival benefit. Systemic therapy is particularly constrained by the inability for precise targeting of tumor cells, thus leading to systemic adverse effects and decreased efficacy in treatment. Nanotherapy holds the potential to overcome these traditional constraints but remains primarily a proof of concept at this juncture with in vivo studies in animal models. Further research and collaboration will ultimately lead to clinical applicability.
Citation	Lee HD, Yuan LY. Nano-revolution in hepatocellular carcinoma: A multidisciplinary odyssey - Are we there yet? World J Hepatol 2024; In press

Received	2024-02-17 01:48
Peer-Review Started	2024-02-17 01:48
To Make the First Decision
Return for Revision	2024-03-31 03:53
Revised	2024-04-08 19:40
Second Decision	2024-04-15 02:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-15 07:30
Articles in Press	2024-04-15 07:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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