| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Bletilla striata polysaccharides alleviate metabolic dysfunction-associated steatotic liver disease through enhancing hepatocyte RelA/HNF1α signaling
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Huai He, Li-Li Ou, Jin-Lian Jiang, Yun-Fen Chen, Aikedaimu Abudukeremu, Yuan Xue, Mao-Yuan Mu, Wei-Wei Zhong, De-Lin Xu, Xuan-Yu Meng and Ya-Qun Guan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 32260089 |
| Science and Technology Research Foundation of Guizhou Province |
No. QKHJC-ZK (2022) YB642 |
| Science and Technology Research Foundation of Hubei Province |
No. 2022BCE030 |
| Science and Technology Research Foundation of Changzhou City |
No. CE20225040 |
| Science and Technology Research Foundation of Zunyi City |
No. ZSKHHZ (2022) 344 |
| Science and Technology Research Foundation of Zunyi City |
No. ZSKHHZ (2022) 360 |
| WBE Liver Fibrosis Foundation |
No. CFHPC2025028 |
|
| Corresponding Author |
Ya-Qun Guan, MD, Professor, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang Key Laboratory of Molecular Biology for Endemic Diseases, Department of Pathology, School of Basic Medical Sciences, Xinjiang Medical University, No. 393 Xinyi Road, Urumqi 830000, Xinjiang Uyghur Autonomous Region, China. yaqunguan557@xjmu.edu.cn |
| Key Words |
Bletilla striata polysaccharides; Metabolic dysfunction-associated steatotic liver disease; Nuclear factor kappa B p65/hepatocyte nuclear factor-1 alpha signaling; Endoplasmic reticulum stress; Oxidative stress; Lipid metabolism reprogramming |
| Core Tip |
This study aimed to investigate the therapeutic effects and mechanisms of Bletilla striata polysaccharides (BSP) on metabolic dysfunction-associated steatotic liver disease (MASLD). Treatment with BSP ameliorates MASLD by enhancing the nuclear factor kappa B p65 (RelA)/hepatocyte nuclear factor-1 alpha (HNF1α) signaling in hepatocytes, which remodels ER stress and oxidative stress responses, and reduces lipid metabolism disorders, and necroptosis. The results suggest that targeting hepatocyte RelA/HNF1α signaling may be a new intervention for treating MASLD, and BSP may be a potential reagent for the treatment of MASLD. |
| Citation |
<p>He YH, Ou LL, Jiang JL, Chen YF, Abudukeremu A, Xue Y, Mu MY, Zhong WW, Xu DL, Meng XY, Guan YQ. Bletilla striata polysaccharides alleviate metabolic dysfunction-associated steatotic liver disease through enhancing hepatocyte RelA/HNF1α signaling. <i>World J Gastroenterol</i> 2025; 31(4): 93179</p> |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
