Publication Name	World Journal of Gastroenterology
Manuscript ID	93257
Country	Spain

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Present and future of new systemic therapies for early and intermediate stages of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Juan Jose Urquijo-Ponce, Carlos Alventosa-Mateu, Mercedes Latorre-Sánchez, Inmaculada Castelló-Miralles and Moisés Diago
Funding Agency and Grant Number
Corresponding Author	Carlos Alventosa-Mateu, MD, PhD, Doctor, Hepatology Unit, Department of Digestive Diseases, Consorcio Hospital General Universitario of Valencia, Av Tres Cruces 2, Valencia 46014, Spain. almacar84@hotmail.com
Key Words	Hepatocellular carcinoma; Early stage; Intermediate stage; Neoadjuvant; Adjuvant; Systemic therapy
Core Tip	This review provides an updated analysis (up to March 2024) of the current data about the new systemic therapies for the hepatocellular carcinoma (HCC) in the early and intermediate stages; specially focusing the findings of neoadjuvant and adjuvant systemic therapies after a treatment with curative intent, for prevention of HCC recurrence. Finally, we discuss about the potential benefits of these new systemic therapies for early and intermediate stages of HCC and their future impact in the HCC treatment schedules.
Citation	Urquijo-Ponce JJ, Alventosa-Mateu C, Latorre-Sánchez M, Castelló-Miralles I, Diago M. Present and future of new systemic therapies for early and intermediate stages of hepatocellular carcinoma. World J Gastroenterol 2024; In press

Received	2024-02-22 21:12
Peer-Review Started	2024-02-22 21:12
To Make the First Decision
Return for Revision	2024-03-08 00:59
Revised	2024-04-08 21:10
Second Decision	2024-04-26 02:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-26 05:05
Articles in Press	2024-04-26 05:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com