Publication Name	World Journal of Clinical Cases
Manuscript ID	93582
Country	China

Category	Dermatology
Manuscript Type	Clinical and Translational Research
Article Title	Exploring the potential mechanism of WuFuYin against hypertrophic scar using network pharmacology and molecular docking
Manuscript Source	Unsolicited Manuscript
All Author List	Shu-Yang Zhang, Song-Xue Guo, Lei-Lei Chen, Jia-Yan Zhu, Ming-Sheng Hou, Jia-Ke Lu and Xue-Xiang Shen
Funding Agency and Grant Number	Funding Agency Grant Number 2022 Shaoxing City Health Science and Technology Program (Health Science and Technology Program) No. 2022KY050
Corresponding Author	Xue-Xiang Shen, MD, Associate Chief Physician, Department Of General Surgery, Shaoxing Hospital of Traditional Chinese Medicine, No. 641 Renmin Middle Road, Yuecheng District, Shaoxing 312000, Zhejiang Province, China. zsyzsy0522@163.com
Key Words	WuFuYin; Hypertrophic scar; Network pharmacology; Molecular docking; Enrichment analysis
Core Tip	This study identified 8 hub genes [CKD2, ABCC1, MMP2, MMP9, glycogen synthase kinase 3 beta (GSK3B), PRARG, MMP3, and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma (PIK3CG)] and five key compounds (MOL004941, MOL004935, MOL004866, MOL004993, and MOL004989) in the WuFuYin (WFY) as an effective treatment for hypertrophic scar (HTS). We found that PI3K-Akt pathway played a crucial role in the WFY. The results of molecular docking showed that GSK3B and cyclin dependent kinase 2 affected HTS through targeting MOL004941, MOL004989, and MOL004993.
Citation	Zhang SY, Guo SX, Chen LL, Zhu JY, Hou MS, Lu JK, Shen XX. Exploring the potential mechanism of WuFuYin against hypertrophic scar using network pharmacology and molecular docking. World J Clin Cases 2024; In press

Received	2024-03-01 08:46
Peer-Review Started	2024-03-01 08:46
To Make the First Decision
Return for Revision	2024-04-09 04:46
Revised	2024-04-23 09:38
Second Decision	2024-04-30 02:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-30 05:31
Articles in Press	2024-04-30 05:31
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ISSN	2307-8960 (online)
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