Publication Name	World Journal of Clinical Cases
Manuscript ID	93660
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Editorial
Article Title	Pearls of meta-analyses and systematic review in scientific evidence
Manuscript Source	Invited Manuscript
All Author List	Sunny Chi Lik Au
Funding Agency and Grant Number
Corresponding Author	Sunny Chi Lik Au, MBChB, Chief Doctor, Surgeon, Department of Ophthalmology, Tung Wah Eastern Hospital, 9/F, MO Office, Lo Ka Chow Memorial Ophthalmic Centre, 19 Eastern Hospital Road, Causeway Bay, Hong Kong , China. kilihcua@gmail.com
Key Words	Meta-analysis; Systematic review; Methodology; Research; Journal; Academic
Core Tip	Scientific evidence evolves from case reports to randomized controlled trials. Systematic reviews and meta-analyses are crucial but can be flawed due to limited information, the so called: “Garbage in, Garbage out”. In running the meta-analysis, mathematical pooling can be invalidated by study heterogeneity, poor study quality, and publication bias. Remedial measures include exploring heterogeneity, restricting meta-analysis to systematic review in case of insufficient information, and addressing different types of bias. Remember, the pearl of meta-analyses relies on quality over quantity in evidence synthesis.
Citation	Au SCL. Pearls of meta-analyses and systematic review in scientific evidence. World J Clin Cases 2024; In press

Received	2024-03-03 09:55
Peer-Review Started	2024-03-03 09:55
To Make the First Decision
Return for Revision	2024-04-10 04:25
Revised	2024-04-10 14:09
Second Decision	2024-04-23 02:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-23 08:56
Articles in Press	2024-04-23 08:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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