Publication Name	World Journal of Clinical Cases
Manuscript ID	93673
Country	China

Category	Otorhinolaryngology
Manuscript Type	Case Control Study
Article Title	Therapeutic efficacy of methylprednisolone sodium succinate via diverse administration routes for mid- to high-frequency sudden sensorineural hearing loss
Manuscript Source	Unsolicited Manuscript
All Author List	Xiang-Da Meng, Ting-Ting Li and Li-Min Deng
Funding Agency and Grant Number
Corresponding Author	Li-Min Deng, N/A, N/A, Department of Facial Ward, The First Affiliated Hospital of Qiqihar Medical University, Fulerji District, Qiqihar 161041, Heilongjiang Province, China. 15946509798@163.com
Key Words	Sudden loss of hearing at middle- and high-frequency of the descending type; Methylprednisolone sodium succinate; Intratympanic injection; Intravenous injection
Core Tip	This retrospective analysis compares the therapeutic effectiveness of methylprednisolone sodium succinate (MPSS) administered via different routes in combination with conventional drugs for mid to high-frequency sudden sensorineural hearing loss (SSNHL). Intratympanic (IT) injection of MPSS combined with conventional treatment demonstrates superior efficacy and safety compared to systemic administration via intravenous infusion and solely IT injection of MPSS, leading to significant improvements in patients' hearing thresholds, speech recognition rates, and symptom disappearance times, as well as lower adverse reaction and recurrence rates. This approach provides valuable insights for optimizing treatment strategies for mid to high-frequency SSNHL.
Citation	Meng XD, Li TT, Deng LM. Therapeutic efficacy of methylprednisolone sodium succinate via diverse administration routes for mid- to high-frequency sudden sensorineural hearing loss. World J Clin Cases 2024; In press

Received	2024-03-03 15:07
Peer-Review Started	2024-03-03 15:07
To Make the First Decision
Return for Revision	2024-04-10 04:20
Revised	2024-04-24 07:45
Second Decision	2024-05-08 02:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-05-08 06:48
Articles in Press	2024-05-08 06:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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