Publication Name	World Journal of Clinical Cases
Manuscript ID	93679
Country	China

Category	Respiratory System
Manuscript Type	Retrospective Study
Article Title	Study on the efficacy of early treatment with pirfenidone on lung function of idiopathic pulmonary fibrosis patients
Manuscript Source	Unsolicited Manuscript
All Author List	Ying Lei, Jian-Hui Sheng, Xu-Ru Jin, Xian-Bing Liu, Xiao-Yan Zheng and Xiao-Hua Xu
Funding Agency and Grant Number
Corresponding Author	Xiao-Hua Xu, MM, Researcher, Department of Pulmonary and Critical Care Medicine, The Quzhou Affiliate Hospital of Wenzhou Medical University, No. 100 Minjiang Avenue, Quzhou 324000, Zhejiang Province, China. xxh406302383@163.com
Key Words	Pirfenidone; Early intervention; Idiopathic pulmonary fibrosis; Pulmonary function; Effect evaluation
Core Tip	The purpose of this study was to assess the effects of pirfenidone in the early treatment of idiopathic pulmonary fibrosis (IPF) on lung function in patients. A retrospective analysis was conducted on 113 patients with IPF. These patients were categorized into two groups: A control group (n = 53) and an observation group (n = 60). In the control group, patients received routine therapy in combination with methylprednisolone tablets, while the observation group received routine therapy along with pirfenidone. Eventually we came to the conclusion that the prompt initiation of pirfenidone treatment in individuals diagnosed with idiopathic pulmonary fibrosis can enhance pulmonary function, elevate inflammatory factor levels, and increase the distance covered in the 6-minute walk test. This intervention is conducive to effectively decreasing the occurrence of adverse reactions in patients.
Citation	<p>Lei Y, Sheng JH, Jin XR, Liu XB, Zheng XY, Xu XH. Study on the efficacy of early treatment with pirfenidone on lung function of idiopathic pulmonary fibrosis patients. <i>World J Clin Cases</i> 2024; 12(22): 4913-4923</p>

Received	2024-03-03 16:52
Peer-Review Started	2024-03-03 16:52
To Make the First Decision
Return for Revision	2024-04-22 20:01
Revised	2024-05-10 17:51
Second Decision	2024-06-06 02:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-06-07 08:57
Articles in Press	2024-06-07 08:57
Publication Fee Transferred	2024-06-13 15:17
Edit the Manuscript by Language Editor	2024-06-25 05:50
Typeset the Manuscript	2024-06-29 06:27

ISSN	2307-8960 (online)
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