Publication Name	World Journal of Clinical Cases
Manuscript ID	93844
Country	China

Category	Ophthalmology
Manuscript Type	Clinical and Translational Research
Article Title	Causal association between 25-hydroxyvitamin D status and cataract development: A two-sample Mendelian randomization study
Manuscript Source	Unsolicited Manuscript
All Author List	Chun-Hui Wang and Zhi-Kun Xin
Funding Agency and Grant Number
Corresponding Author	Zhi-Kun Xin, BMed, Chief Physician, Department of Ophthalmology, Aviation General Hospital, No. 3 Anwai Beiyuan Courtyard, Anli Road, Chaoyang District, Beijing 100010, China. xzkavic@163.com
Key Words	Cataract; 25-hydroxyvitamin D; Mendelian randomization; Single nucleotide polymorphism; Causal relationship
Core Tip	Previous studies have documented the role of vitamin D in cataract development, yet investigations into the causal relationship between 25-(OH)D status and cataract onset are still lacking. Using Mendelian randomization, our study established a significant association between elevated 25-(OH)D levels and increased cataract risk. Additionally, a search of the human genotype-phenotype association database revealed no potentially relevant risk-factor single nucleotide polymorphisms. These findings need to be verified by further experiments.
Citation	Wang CH, Xin ZK. Causal association between 25-hydroxyvitamin D status and cataract development: A two-sample Mendelian randomization study. World J Clin Cases 2024; In press

Received	2024-03-10 12:45
Peer-Review Started	2024-03-10 12:45
To Make the First Decision
Return for Revision	2024-04-17 09:45
Revised	2024-04-23 06:53
Second Decision	2024-04-28 02:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-28 09:52
Articles in Press	2024-04-28 09:52
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ISSN	2307-8960 (online)
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