Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	93884
Country	China

Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	N-glycosylation of Wnt3 regulates the progression of hepatocellular carcinoma by affecting Wnt/β-catenin signal pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Xin-Zhan Zhang, Xiao-Chuan Mo, Zhu-Ting Wang, Rong Sun and Da-Quan Sun
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81560390 the Guizhou Medical University Cultivation Project of the National Natural Science Foundation of China 22NSFCP02 Basic Research Project of Science and Technology Department of Guizhou Province ZK[2024] General 136
Corresponding Author	Da-Quan Sun, PhD, Assistant Professor, Department of Biochemistry and Molecular Biology & Research Center for Basic Medical Sciences, Guizhou Medical University, Ankang Avenue, Machang Town, Guian New District, Guiyang 550025, Guizhou Province, China. sundq04@sina.com
Key Words	Wnt3; N-glycosylation; Hepatocellular carcinoma; Liver cancer; Wnt/β-catenin; FZD7
Core Tip	Our study reveals that Wnt3 undergoes N-glycosylation modification at two specific sites (Asn90 and Asn301). Mutation of these sites impairs the stability and function of Wnt3, reducing its binding ability to FZD7 and downregulating the Wnt/β-catenin signaling pathway. Consequently, cell proliferation, migration, and invasion are attenuated in hepatocellular carcinoma cells. These findings suggest that targeting Wnt3 N-glycosylation could be a potential therapeutic strategy for liver cancer.
Citation	Zhang XZ, Mo XC, Wang ZT, Sun R, Sun DQ. N-glycosylation of Wnt3 regulates the progression of hepatocellular carcinoma by affecting Wnt/β-catenin signal pathway. World J Gastrointest Oncol 2024; In press

Received	2024-03-07 10:01
Peer-Review Started	2024-03-07 10:01
To Make the First Decision
Return for Revision	2024-04-23 01:17
Revised	2024-04-25 08:50
Second Decision	2024-04-28 02:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-28 05:58
Articles in Press	2024-04-28 05:58
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ISSN	1948-5204 (online)
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