Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	93923
Country	Malaysia

Category	Cell Biology
Manuscript Type	Editorial
Article Title	Human β-defensin-1 activates autophagy in human colon cancer cells via regulation of long non-coding RNA TCONS_00014506
Manuscript Source	Invited Manuscript
All Author List	Nabil Eid and Fabian Davamani
Funding Agency and Grant Number
Corresponding Author	Nabil Eid, Doctor, MD, PhD, Academic Editor, Assistant Professor, Senior Lecturer, Senior Scientist, Anatomy Department, Division of Human Biology, School of Medicine, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my
Key Words	Colon cancer; Human β-defensin-1; Long noncoding RNA; Mammalian target of rapamycin; Autophagy; LC3-II; Beclin-1; Autophagy flux
Core Tip	Autophagy is an essential mechanism for clearing harmful cellular components, specifically upon exposure to various stressors such as chemotherapy. The activation of autophagy in colon cancer cells under human β-defensin-1 treatment is mediated by mammalian target of rapamycin suppression and upregulation of long noncoding RNAs (lncRNA) TCONS_00014506. Targeting this lncRNA could have prognostic, diagnostic, and therapeutic implications in colon cancer.
Citation	<p>Eid N, Davamani F. Human β-defensin-1 activates autophagy in human colon cancer cells via regulation of long non-coding RNA TCONS_00014506. <i>World J Gastrointest Oncol</i> 2024; 16(7): 2894-2901</p>

Received	2024-03-07 16:00
Peer-Review Started	2024-03-07 16:00
To Make the First Decision
Return for Revision	2024-04-18 01:37
Revised	2024-04-26 11:11
Second Decision	2024-05-14 02:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-05-14 03:12
Articles in Press	2024-05-14 03:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-06-19 09:32

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com