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5/14/2024 3:12:30 AM | Browse: 40 | Download: 0
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 93923
Country Malaysia
Category Cell Biology
Manuscript Type Editorial
Article Title Human β-defensin-1 activates autophagy in human colon cancer cells via regulation of long non-coding RNA TCONS_00014506
Manuscript Source Invited Manuscript
All Author List Nabil Eid and Fabian Davamani
Funding Agency and Grant Number
Corresponding Author Nabil Eid, Doctor, MD, PhD, Academic Editor, Assistant Professor, Senior Lecturer, Senior Scientist, Anatomy Department, Division of Human Biology, School of Medicine, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my
Key Words Colon cancer; Human β-defensin-1; Long noncoding RNA; Mammalian target of rapamycin; Autophagy; LC3-II; Beclin-1; Autophagy flux
Core Tip Autophagy is an essential mechanism for clearing harmful cellular components, specifically upon exposure to various stressors such as chemotherapy. The activation of autophagy in colon cancer cells under human β-defensin-1 treatment is mediated by mammalian target of rapamycin suppression and upregulation of long noncoding RNAs (lncRNA) TCONS_00014506. Targeting this lncRNA could have prognostic, diagnostic, and therapeutic implications in colon cancer.
Citation Eid N, Davamani F. Human β-defensin-1 activates autophagy in human colon cancer cells via regulation of long non-coding RNA TCONS_00014506. World J Gastrointest Oncol 2024; In press
Received
2024-03-07 16:00
Peer-Review Started
2024-03-07 16:00
To Make the First Decision
Return for Revision
2024-04-18 01:37
Revised
2024-04-26 11:11
Second Decision
2024-05-14 02:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-05-14 03:12
Articles in Press
2024-05-14 03:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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