Publication Name	World Journal of Gastroenterology
Manuscript ID	94050
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Leech Poecilobdella manillensis protein extract ameliorated hyperuricemia by restoring gut microbiota dysregulation and affecting serum metabolites
Manuscript Source	Unsolicited Manuscript
All Author List	Xia Liu, Xing-Qiu Liang, Tian-Cai Lu, Zhe Feng, Min Zhang, Nan-Qing Liao, Feng-Lian Zhang, Bo Wang and Li-Sheng Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82160843
Corresponding Author	Li-Sheng Wang, MD, PhD, Professor, Medical College, Guangxi University, No. 100 Daxue East Road, Nanning 530004, Guangxi Zhuang Autonomous Region, China. lswang@gxu.edu.cn
Key Words	Gut microbiota; Metabolism; Multi-omics; Poecilobdella manillensis; Sphingolipid metabolism pathway; Galactose metabolism pathway; Hyperuricemia
Core Tip	This study reveals the novel therapeutic potential of Poecilobdella manillensis in treating hyperuricemia (HUA) through a dual mechanism: The direct modulation of uric acid levels and restoration of renal and intestinal barriers. Importantly, it highlights the role of proteins in Poecilobdella manillensis in rectifying gut microbiota dysbiosis and adjusting key metabolic pathways, most notably, sphingolipid and galactose metabolism. These findings highlight the multi-target, multi-channel effects of Poecilobdella manillensis treatment for HUA and provide fundamental data for the clinical use of HUA treatments.
Citation	<p>Liu X, Liang XQ, Lu TC, Feng Z, Zhang M, Liao NQ, Zhang FL, Wang B, Wang LS. Leech Poecilobdella manillensis protein extract ameliorated hyperuricemia by restoring gut microbiota dysregulation and affecting serum metabolites. <i>World J Gastroenterol</i> 2024; 30(29): 3488-3510</p>

Received	2024-03-10 12:52
Peer-Review Started	2024-03-10 12:52
To Make the First Decision
Return for Revision	2024-06-04 04:45
Revised	2024-06-20 02:25
Second Decision	2024-07-19 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-19 05:44
Articles in Press	2024-07-19 05:44
Publication Fee Transferred	2024-07-19 09:43
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-07-24 03:15

ISSN	1007-9327 (print) and 2219-2840 (online)
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