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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 94950
Country China
Category Oncology
Manuscript Type Clinical and Translational Research
Article Title Protein tyrosine phosphatase non-receptor II: A possible biomarker of poor prognosis in hepatocellular carcinoma and mediates immune evasion  
Manuscript Source Unsolicited Manuscript
All Author List Hui-Yuan Li, Yi-Ming Jing, Xue Shen, Ming-Yue Tang, Hong-Hong Shen, Xin-Wei Li, Zi-Shu Wang and Fang Su
Funding Agency and Grant Number
Corresponding Author Fang Su, Doctor, MD, PhD, Academic Research, Researcher, Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Longzihu District, Bengbu 233000, Anhui Province, China. sufang2899@163.com
Key Words Protein tyrosine phosphatase non-receptor 2; Hepatocellular carcinoma; Immune evasion; Biomarker; Immunotherapy; Prognosis
Core Tip Our results analysed by immunohistochemical staining, qRT-PCR and immunoblotting in combination with the TCGA database showed that protein tyrosine phosphatase non-receptor 2 (PTPN2) was highly expressed in patients with hepatocellular carcinoma and was associated with poor prognosis. KEGG enrichment analysis then showed that PTPN2 was associated with multiple pathways, including cancer-related pathway, Notch signalling pathway and MAPK signalling pathway. Analysis by constructing a risk model for PTPN2 revealed that immune escape was significantly enhanced in the high-risk group compared with the low-risk group.In this study, PTPN2 was investigated from multiple biological perspectives, and was found to serve as a biomarker of poor prognosis in hepatocellular carcinoma and to mediate immune escape.  
Citation Li HY, Jing YM, Shen X, Tang MY, Shen HH, Li XW, Wang ZS, Su F. Protein tyrosine phosphatase non-receptor II: A possible biomarker of poor prognosis in hepatocellular carcinoma and mediates immune evasion. World J Gastrointest Oncol 2024; In press
2024-03-28 11:07
Peer-Review Started
2024-03-28 11:07
To Make the First Decision
Return for Revision
2024-05-01 19:38
2024-06-03 16:50
Second Decision
2024-07-08 02:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-07-08 07:51
Articles in Press
2024-07-08 07:51
Publication Fee Transferred
2024-07-17 11:41
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ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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