Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	94950
Country	China

Category	Oncology
Manuscript Type	Clinical and Translational Research
Article Title	Protein tyrosine phosphatase non-receptor II: A possible biomarker of poor prognosis and mediator of immune evasion in hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Hui-Yuan Li, Yi-Ming Jing, Xue Shen, Ming-Yue Tang, Hong-Hong Shen, Xin-Wei Li, Zi-Shu Wang and Fang Su
Funding Agency and Grant Number
Corresponding Author	Fang Su, Doctor, MD, PhD, Academic Research, Researcher, Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Longzihu District, Bengbu 233000, Anhui Province, China. sufang2899@163.com
Key Words	Protein tyrosine phosphatase non-receptor 2; Hepatocellular carcinoma; Immune evasion; Biomarker; Immunotherapy; Prognosis
Core Tip	Our results analysed by immunohistochemical staining, qRT-PCR and immunoblotting in combination with the TCGA database showed that protein tyrosine phosphatase non-receptor 2 (PTPN2) was highly expressed in patients with hepatocellular carcinoma and was associated with poor prognosis. KEGG enrichment analysis then showed that PTPN2 was associated with multiple pathways, including cancer-related pathway, Notch signalling pathway and MAPK signalling pathway. Analysis by constructing a risk model for PTPN2 revealed that immune escape was significantly enhanced in the high-risk group compared with the low-risk group.In this study, PTPN2 was investigated from multiple biological perspectives, and was found to serve as a biomarker of poor prognosis in hepatocellular carcinoma and to mediate immune escape.
Citation	<p>Li HY, Jing YM, Shen X, Tang MY, Shen HH, Li XW, Wang ZS, Su F. Protein tyrosine phosphatase non-receptor II: A possible biomarker of poor prognosis and mediator of immune evasion in hepatocellular carcinoma. <i>World J Gastrointest Oncol</i> 2024; 16(9): 3913-3931</p>

Received	2024-03-28 11:07
Peer-Review Started	2024-03-28 11:07
To Make the First Decision
Return for Revision	2024-05-01 19:38
Revised	2024-06-03 16:50
Second Decision	2024-07-08 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-08 07:51
Articles in Press	2024-07-08 07:51
Publication Fee Transferred	2024-07-17 11:41
Edit the Manuscript by Language Editor	2024-07-21 23:07
Typeset the Manuscript	2024-07-31 05:37

ISSN	1948-5204 (online)
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