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Articles in Press
6/21/2024 7:07:25 AM | Browse: 130 | Download: 0
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Retrospective Study |
| Article Title |
SCN1A rs6732655A/T polymorphism: Diagnostic and therapeutic insights for drug-resistant epilepsy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Aroop Viswas, Pradeep K Dabla, Dharmsheel Shrivastav, Swapan Gupta, Manisha Yadav, Subhash Yadav and Bidhan Chandra Koner |
| Funding Agency and Grant Number |
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| Corresponding Author |
Pradeep K Dabla, MD, Professor, Department of Biochemistry, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, 1, Jawaharlal Nehru Marg, 64 Khamba Raj Ghat, New Delhi 110002, Delhi, India. pradeep_dabla@yahoo.com |
| Key Words |
Epilepsy; Drug resistance; SCN1A gene; Pro-inflammatory cytokines; Genetic factors |
| Core Tip |
Epilepsy poses a substantial global health burden due to its recurrent seizures, with a subset of patients proving resistant to current treatments, leading to increased mortality and decreased quality of life. Genetic factors, including SCN1A gene variants, and their pro-inflammatory cytokines response [interleukin (IL)-1β, IL-6, and high mobility group box 1 protein (HMGB1)], play crucial roles in drug resistance. This study investigates the correlation between SCN1A gene variants (rs6732655A/T) and drug resistance in epilepsy, confirming higher levels of IL-1β, IL-6, and HMGB1 in drug-resistant cases and suggesting specific genotypes (AA and AT) as potential biomarkers for oxidative stress and neuroinflammation in drug-resistant idiopathic epilepsy. |
| Citation |
Viswas A, Dabla PK, Shrivastav D, Gupta S, Yadav M, Yadav S, Koner BC. SCN1A rs6732655A/T polymorphism: Diagnostic and therapeutic insights for drug-resistant epilepsy. World J Exp Med 2024; 14(3): 94999 |
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Received |
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2024-03-29 14:16 |
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Peer-Review Started |
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2024-03-29 14:16 |
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First Decision by Editorial Office Director |
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2024-05-03 19:15 |
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Return for Revision |
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2024-05-06 03:28 |
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Revised |
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2024-05-20 17:56 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-06-21 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-06-21 07:07 |
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Articles in Press |
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2024-06-21 07:07 |
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Edit the Manuscript by Language Editor |
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2024-06-25 23:43 |
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Typeset the Manuscript |
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2024-07-24 07:54 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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