Publication Name	World Journal of Clinical Cases
Manuscript ID	95168
Country	China

Category	Biophysics
Manuscript Type	Case Report
Article Title	Application of accelerated continuous theta burst stimulation in treatment-resistant depression: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Gui-Lan Sun, Min-Min Wang and Xiao-Mei Zhang
Funding Agency and Grant Number	Funding Agency Grant Number The Zhejiang Natural Science Foundation of China, China No. LTGY23H090013 The Natural Science Foundation of Zhejiang Province, China No. LQ20H170003
Corresponding Author	Min-Min Wang, Doctor, Associate Professor, Department of Biomedical Engineering, Zhejiang University, No. 38 ZheDa Road, Hangzhou 310027, Zhejiang Province, China. minminwang@zju.edu.cn
Key Words	Treatment-resistant depression; Antipsychotic medications; Theta burst stimulation; Transcranial magnetic stimulation; Accelerated; High-dose; Case report
Core Tip	Major depressive disorder (MDD) is a mental illness characterized by persistent feelings of low mood, with high prevalence, suicide rates, and mortality. It is estimated that about one-third of MDD patients respond effectively to traditional antidepressant medication, while those who remain unresponsive to at least two types of antidepressants are referred to as having treatment-resistant depression (TRD). This case report describes the application of high-dose accelerated continuous theta burst stimulation (a-cTBS) in a patient with TRD who had previously failed to respond to conventional treatments, including medication and standard repetitive transcranial magnetic stimulation protocol (intermittent theta burst stimulation). The outcomes of this intervention suggest that a-cTBS may represent a viable alternative for patients who do not benefit from existing treatment modalities. This case underscores the importance of exploring innovative approaches in the management of TRD and suggests that a-cTBS could be considered as a potential therapeutic option in this population.
Citation	Sun GL, Wang MM, Zhang XM. Application of accelerated continuous theta burst stimulation in treatment-resistant depression: A case report. World J Clin Cases 2024; In press

Received	2024-04-03 02:12
Peer-Review Started	2024-04-03 02:12
To Make the First Decision
Return for Revision	2024-08-09 07:07
Revised	2024-08-21 17:30
Second Decision	2024-09-03 02:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-09-03 10:33
Articles in Press	2024-09-03 10:33
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ISSN	2307-8960 (online)
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