Publication Name	World Journal of Clinical Cases
Manuscript ID	95994
Country	China

Category	Obstetrics & Gynecology
Manuscript Type	Clinical and Translational Research
Article Title	Modifiable factors mediating the effects of educational attainment on gestational diabetes mellitus: A two-step Mendelian randomization study
Manuscript Source	Unsolicited Manuscript
All Author List	Ming-Yue Ma and Ya-Song Zhao
Funding Agency and Grant Number
Corresponding Author	Ya-Song Zhao, PhD, Researcher, Department of Nursing, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. zys18940252012@163.com
Key Words	Educational status; Gestational diabetes mellitus; Metabolism; Lifestyle factors; Mendelian randomization analysis
Core Tip	Studies have shown that the level of maternal education is associated with the risk of developing gestational diabetes mellitus (GDM). In this study, we sought to identify the specific modifiable risk factors that mediate the causal relationship between the level of maternal education and the likelihood of developing GDM. We performed Mendelian randomization analyses based on publicly available data obtained in a number of genome-wide association studies of European populations. Our findings indicate that a genetically predicted higher level of maternal education is associated with a lower GDM risk and that four modifiable metabolic factors contribute to mediating this association, namely, waist-to-hip ratio, body mass index, and the contents of high-density lipoprotein cholesterol and apolipoprotein A-1.
Citation	<p>Ma MY, Zhao YS. Modifiable factors mediating the effects of educational attainment on gestational diabetes mellitus: A two-step Mendelian randomization study. <i>World J Clin Cases</i> 2024; 12(26): 5937-5945</p>

Received	2024-04-24 02:27
Peer-Review Started	2024-04-24 02:27
To Make the First Decision
Return for Revision	2024-06-19 11:01
Revised	2024-07-01 14:57
Second Decision	2024-07-10 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-10 09:04
Articles in Press	2024-07-10 09:04
Publication Fee Transferred	2024-07-11 00:10
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-07-18 07:50

ISSN	2307-8960 (online)
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