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Publication Name World Journal of Clinical Cases
Manuscript ID 95994
Country China
Category Obstetrics & Gynecology
Manuscript Type Clinical and Translational Research
Article Title Modifiable factors mediating the effects of educational attainment on gestational diabetes mellitus: A two-step Mendelian randomization study
Manuscript Source Unsolicited Manuscript
All Author List Ming-Yue Ma and Ya-Song Zhao
Funding Agency and Grant Number
Corresponding Author Ya-Song Zhao, PhD, Researcher, Department of Nursing, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. zys18940252012@163.com
Key Words Educational status; Gestational diabetes mellitus; Metabolism; Lifestyle factors; Mendelian randomization analysis
Core Tip Studies have shown that the level of maternal education is associated with the risk of developing gestational diabetes mellitus (GDM). In this study, we sought to identify the specific modifiable risk factors that mediate the causal relationship between the level of maternal education and the likelihood of developing GDM. We performed Mendelian randomization analyses based on publicly available data obtained in a number of genome-wide association studies of European populations. Our findings indicate that a genetically predicted higher level of maternal education is associated with a lower GDM risk and that four modifiable metabolic factors contribute to mediating this association, namely, waist-to-hip ratio, body mass index, and the contents of high-density lipoprotein cholesterol and apolipoprotein A-1.
Citation Ma MY, Zhao YS. Modifiable factors mediating the effects of educational attainment on gestational diabetes mellitus: A two-step Mendelian randomization study. World J Clin Cases 2024; In press
2024-04-24 02:27
Peer-Review Started
2024-04-24 02:27
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Return for Revision
2024-06-19 11:01
2024-07-01 14:57
Second Decision
2024-07-10 02:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-07-10 09:04
Articles in Press
2024-07-10 09:04
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2024-07-11 00:10
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ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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