Publication Name	World Journal of Orthopedics
Manuscript ID	96065
Country	Lebanon

Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Intra-articular interventions in osteoarthritis: Navigating the landscape of hyaluronic acid, mesenchymal stem cells, and platelet-rich plasma
Manuscript Source	Unsolicited Manuscript
All Author List	Somar Soufan, Joenne Al Khoury, Zahi Hamdan and Mohamad Ali Rida
Funding Agency and Grant Number
Corresponding Author	Mohamad Ali Rida, MD, Assistant Professor, Department of Internal Medicine, Clemenceau Medical Center, Clemenceau, Beirut 12345, Lebanon. mohamad.ali.rida@gmail.com
Key Words	Stem cell; Hyaluronic acid; Platelets; Osteoarthritis, Viscosupplementation
Core Tip	Osteoarthritis significantly impacts patients by causing pain, functional decline, and reduced quality of life. Traditional treatments mainly manage symptoms, with no disease-modifying interventions established. This review examines intra-articular treatments, including hyaluronic acid (HA), mesenchymal stem cells (MSCs), and platelet-rich plasma (PRP). HA injections show varied outcomes, requiring detailed understanding. MSCs, especially adipose-derived MSCs, demonstrate sustained benefits over six months, while bone marrow-derived MSCs are less effective. PRP is effective for long-term pain relief and quality of life improvement. Personalized, evidence-based approaches are crucial to enhance treatment efficacy and patient outcomes
Citation	<p>Soufan S, Al Khoury J, Hamdan Z, Rida MA. Intra-articular interventions in osteoarthritis: Navigating the landscape of hyaluronic acid, mesenchymal stem cells, and platelet-rich plasma. <i>World J Orthop</i> 2024; 15(8): 704-712</p>

Received	2024-04-25 18:56
Peer-Review Started	2024-04-25 18:56
To Make the First Decision
Return for Revision	2024-07-02 06:06
Revised	2024-07-13 15:24
Second Decision	2024-07-29 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-29 08:31
Articles in Press	2024-07-29 08:31
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-08-03 12:36
Typeset the Manuscript	2024-08-05 08:39

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com