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7/8/2024 8:08:55 AM | Browse: 33 | Download: 0
Publication Name World Journal of Diabetes
Manuscript ID 96246
Country China
Category Ophthalmology
Manuscript Type Editorial
Article Title Potential prospects of Chinese medicine application in diabetic retinopathy
Manuscript Source Invited Manuscript
All Author List Yi-Mai Zhou, Yuan-Hao Cao, Jing Guo and Lu-Sha Cen
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 82104862
Scientific Research Project Foundation of Zhejiang Chinese Medical University 2023FSYYZZ01 and 2023RCZXZK49
Corresponding Author Lu-Sha Cen, PhD, Attending Doctor, Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), No. 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China. cenlusa2@sina.com
Key Words Diabetic retinopathy; Traditional Chinese medicine; Genipin; Topical application; Advanced glycation end products
Core Tip In this study, in vitro experiments showed that genipin can reverse high glucose-induced damage in cell proliferation and apoptosis, while reducing energy metabolism, oxidative stress, and inflammatory injury induced by high glucose. The in vitro results showed that intravitreal injection with genipin reduced the expression of CHGA, UCP2, and glucose transporter 1 (GLUT1), and the CHGA/UCP2/GLUT1 signalling pathway may play an important role in this process. This study innovatively treated streptozotocin-induced mice with an intraocular injection of genipin, and concluded that genipin ameliorates diabetic retinopathy by downregulating advanced glycation end products, thereby protecting human retinal microvascular endothelial cells.
Citation Zhou YM, Cao YH, Guo J, Cen LS. Potential prospects of Chinese medicine application in diabetic retinopathy. World J Diabetes 2024; In press
Received
2024-04-30 12:30
Peer-Review Started
2024-04-30 12:30
To Make the First Decision
Return for Revision
2024-05-22 05:15
Revised
2024-06-03 09:12
Second Decision
2024-07-08 02:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-07-08 08:08
Articles in Press
2024-07-08 08:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2024-07-16 01:16
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
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