Publication Name	World Journal of Diabetes
Manuscript ID	96246
Country	China

Category	Ophthalmology
Manuscript Type	Editorial
Article Title	Potential prospects of Chinese medicine application in diabetic retinopathy
Manuscript Source	Invited Manuscript
All Author List	Yi-Mai Zhou, Yuan-Hao Cao, Jing Guo and Lu-Sha Cen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82104862 Scientific Research Project Foundation of Zhejiang Chinese Medical University 2023FSYYZZ01 and 2023RCZXZK49
Corresponding Author	Lu-Sha Cen, PhD, Attending Doctor, Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), No. 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China. cenlusa2@sina.com
Key Words	Diabetic retinopathy; Traditional Chinese medicine; Genipin; Topical application; Advanced glycation end products
Core Tip	In this study, in vitro experiments showed that genipin can reverse high glucose-induced damage in cell proliferation and apoptosis, while reducing energy metabolism, oxidative stress, and inflammatory injury induced by high glucose. The in vitro results showed that intravitreal injection with genipin reduced the expression of CHGA, UCP2, and glucose transporter 1 (GLUT1), and the CHGA/UCP2/GLUT1 signalling pathway may play an important role in this process. This study innovatively treated streptozotocin-induced mice with an intraocular injection of genipin, and concluded that genipin ameliorates diabetic retinopathy by downregulating advanced glycation end products, thereby protecting human retinal microvascular endothelial cells.
Citation	<p>Zhou YM, Cao YH, Guo J, Cen LS. Potential prospects of Chinese medicine application in diabetic retinopathy. <i>World J Diabetes</i> 2024; 15(10): 2010-2014</p>

Received	2024-04-30 12:30
Peer-Review Started	2024-04-30 12:30
To Make the First Decision
Return for Revision	2024-05-22 05:15
Revised	2024-06-03 09:12
Second Decision	2024-07-08 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-08 08:08
Articles in Press	2024-07-08 08:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-07-16 01:16

ISSN	1948-9358 (online)
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