Publication Name	World Journal of Experimental Medicine
Manuscript ID	96318
Country	Greece

Category	Surgery
Manuscript Type	Editorial
Article Title	Therapeutic strategies and prognostic challenges in linitis plastica
Manuscript Source	Invited Manuscript
All Author List	Grigorios Christodoulidis, Sara Eirini Agko, Konstantinos Eleftherios Koumarelas and Marina Nektaria Kouliou
Funding Agency and Grant Number
Corresponding Author	Grigorios Christodoulidis, MD, PhD, Department of General Surgery, University Hospital of Larissa, Mezourlo, Larissa 41110, Greece. gregsurg@yahoo.gr
Key Words	Linitis plastica; Surgery; Chemotherapy; Radiotherapy; Treatment strategies; Gastric cancer
Core Tip	Linitis plastica (LP) gastric cancer poses a significant challenge due to its aggressive nature and poor prognosis. Early detection and personalized treatment strategies are essential for improving outcomes in LP patients. While surgery remains the mainstay of treatment, the role of adjuvant chemotherapy and postoperative radiotherapy is still under debate. Neoadjuvant chemotherapy, particularly with regimens such as docetaxel plus oxaliplatin plus-S-1, shows promise in enhancing survival rates for LP patients. Multidisciplinary collaboration and further research are necessary to optimize therapeutic interventions and improve outcomes in this challenging subset of gastric cancer.
Citation	Christodoulidis G, Agko SE, Koumarelas KE, Kouliou MN. Therapeutic strategies and prognostic challenges in linitis plastic. World J Exp Med 2024; In press

Received	2024-08-21 03:11
Peer-Review Started	2024-05-03 09:56
To Make the First Decision
Return for Revision	2024-09-28 18:52
Revised	2024-10-09 21:27
Second Decision	2024-11-29 02:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-29 08:20
Articles in Press	2024-11-29 08:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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