Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	96927
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Impact of oxaliplatin and trastuzumab combination therapy on tumor markers and T lymphocyte subsets for advanced gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Cheng-Wan Zheng, Yun-Mo Yang and Hui Yang
Funding Agency and Grant Number
Corresponding Author	Hui Yang, MMed, Chief Physician, Department of Thyroid Surgery, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou 646000, Sichuan Province, China. yh65011@163.com
Key Words	Advanced gastric cancer; Oxaliplatin; Trastuzumab; Serum tumor markers; T lymphocyte subsets; Predictive biomarkers
Core Tip	An investigation of the effects of oxaliplatin and trastuzumab combination therapy on serum tumor markers and T lymphocyte subsets in patients with advanced gastric cancer (AGC) revealed significant reductions in carcinoembryonic antigen, cancer antigen 19-9, and cancer antigen 72-4 levels, as well as favorable changes in T cell populations. Patients with significantly decreased tumor marker levels and increased CD4+/CD8+ ratio exhibited better treatment responses. The therapy not only targets tumors but also boosts immune responses in patients with AGC. Serum markers and T cell subsets are potential predictive biomarkers for treatment outcomes in patients with AGC receiving this combined treatment.
Citation	<p>Zheng CW, Yang YM, Yang H. Impact of oxaliplatin and trastuzumab combination therapy on tumor markers and T lymphocyte subsets for advanced gastric cancer. <i>World J Gastrointest Oncol</i> 2024; 16(9): 3905-3912</p>

Received	2024-06-05 11:05
Peer-Review Started	2024-06-05 11:05
To Make the First Decision
Return for Revision	2024-06-25 10:56
Revised	2024-07-03 03:59
Second Decision	2024-07-09 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-07-09 06:45
Articles in Press	2024-07-09 06:45
Publication Fee Transferred	2024-07-14 16:24
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-07-29 09:21

ISSN	1948-5204 (online)
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