Publication Name	World Journal of Diabetes
Manuscript ID	97304
Country	China

Category	Urology & Nephrology
Manuscript Type	Basic Study
Article Title	Effect of cuproptosis on acute kidney injury after cardiopulmonary bypass in diabetic patients
Manuscript Source	Unsolicited Manuscript
All Author List	Xi-Jin Deng, Yi-Nan Wang, Chuan-Bao Lv, Zhong-Zhi Qiu, Ling-Xin Zhu, Jing-Hui Shi and Si-Ri-Gu-Leng Sana
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Heilongjiang Province No. LH2022H035 First Affiliated Hospital of Harbin Medical University Foundation No. 2024JQ14
Corresponding Author	Si-Ri-Gu-Leng Sana, PhD, Professor, Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, No. 23 You Zheng Street, Harbin Heilongjiang, Heilongjiang Province, China. sana820816@163.com
Key Words	Cardiopulmonary bypass; Acute kidney injury; Cuproptosis; Diabetes; Copper overload; Iron-sulfur cluster proteins
Core Tip	This study found that cardiopulmonary bypass (CPB) resulted in elevations of copper, lactate, heat shock protein-70 and dihydrolipoamide dehydrogenase in blood and urine in both diabetic and non-diabetic patients. CPB was associated with pathologic and mitochondrial damage in the kidneys of diabetic rats. Cuproptosis-related proteins also appeared to be significantly reduced. CPB- acute kidney injury (AKI) is associated with cuproptosis. Diabetes mellitus is an important factor aggravating CPB-AKI and cuproptosis. We believe this manuscript is valuable for all the researchers who are interested in.
Citation	Deng XJ, Wang YN, Lv CB, Qiu ZZ, Zhu LX, Shi JH, Sana SRGL. Effect of cuproptosis on acute kidney injury after cardiopulmonary bypass in diabetic patients. World J Diabetes 2024; In press

Received	2024-07-10 11:37
Peer-Review Started	2024-07-10 11:37
To Make the First Decision
Return for Revision	2024-08-05 11:55
Revised	2024-08-11 08:03
Second Decision	2024-08-22 03:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-09-05 08:33
Articles in Press	2024-09-05 08:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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