Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	97720
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Effects of postoperative treatment with chemotherapy and cellular immunotherapy on patients with colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Zhen-Yu Ding, Ying Piao, Tong Jiang, Juan Chen, Yi-Nuo Wang, Hui-Ying Yu and Zhen-Dong Zheng
Funding Agency and Grant Number
Corresponding Author	Zhen-Dong Zheng, PhD, Chief Physician, Department of Oncology, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenyang 110016, Liaoning Province, China. zzd_oncologist@163.com
Key Words	Analysis of variables affecting outcomes; Cellular immunotherapy; Chemotherapy; Colorectal cancer; Clinical effects
Core Tip	Adjuvant postoperative therapy for colorectal cancer (CRC) maximizes surgical outcomes while significantly reducing CRC-related mortality. This study analyzes the efficacy of the XELOX regimen combined with dendritic cell-cytokine-induced killer (DC-CIK) cell immunotherapy for postoperative CRC patients and the mediating variables, aiming to provide a useful clinical reference to optimize the efficacy of postoperative CRC treatment. Through a comparative analysis of the XELOX chemotherapy regimen vs XELOX regimen plus DC-CIK immunotherapy therapy across multiple outcome and safety indices, including efficacy, adverse event rates, serum tumor marker levels, and T-cell subset levels, the combination regimen is confirmed to offer greater efficacy than a chemotherapy regimen alone, enhancing patient immunity, increasing physiological antitumor activity, and providing improved treatment safety.
Citation	Ding ZY, Piao Y, Jiang T, Chen J, Wang YN, Yu HY, Zheng ZD. Effects of postoperative treatment with chemotherapy and cellular immunotherapy on patients with colorectal cancer. World J Gastrointest Surg 2024; In press

Received	2024-08-01 08:56
Peer-Review Started	2024-08-01 08:56
To Make the First Decision
Return for Revision	2024-08-21 10:12
Revised	2024-08-30 04:19
Second Decision	2024-09-03 02:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-09-03 08:26
Articles in Press	2024-09-03 08:26
Publication Fee Transferred	2024-09-04 00:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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