Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	97817
Country	United Kingdom

Category	Surgery
Manuscript Type	Retrospective Cohort Study
Article Title	Local excision of early rectal cancer: A multi-centre experience of transanal endoscopic microsurgery from the United Kingdom
Manuscript Source	Invited Manuscript
All Author List	Ahmed Farid, Matthew Tutton, Prem Thambi, TS Gill and Jim Khan
Funding Agency and Grant Number
Corresponding Author	Jim Khan, FCPS, FRCS (Gen Surg), MSc, PhD, Professor, Surgeon, Surgical Oncologist, Department of General Surgery, Portsmouth Hospitals NHS Trust, Queen Alexandra Hospital, Southwick Hill Road, Cosham, Portsmouth PO6 3LY, Hampshire, United Kingdom. mkhan702@aol.com
Key Words	Local excision; Transanal endoscopic microsurgery; Early rectal cancer; Rectum preservation; Rectum saving
Core Tip	In this multi-centre study, Trans-anal endoscopic microsurgery was employed in 222 patients of early rectal cancers (T1-T2/early T3, N0), with acceptable oncologic outcomes and morbidity. The main independent factor of survival was the completeness of local excision, while completion total mesorectal excision did not offer a survival benefit. The limitations of this study were the heterogenicity of the data, its retrospective analysis, and the non-comparative design to the total mesorectal excision, which is the standard of care. However, this rectum preservation strategy can be a substitute in selected patients, especially in the evolving era of precision medicine.
Citation	Farid A, Tutton M, Thambi P, Gill T, Khan J. Local excision of early rectal cancer: A multi-centre experience of transanal endoscopic microsurgery from the United Kingdom. World J Gastrointest Surg 2024; In press

Received	2024-06-09 17:57
Peer-Review Started	2024-06-09 17:57
To Make the First Decision
Return for Revision	2024-07-02 05:12
Revised	2024-07-25 18:41
Second Decision	2024-09-03 02:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-09-03 08:48
Articles in Press	2024-09-03 08:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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