Publication Name	World Journal of Stem Cells
Manuscript ID	97852
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Letter to the Editor
Article Title	Innovative hydrogel delivery of bone marrow stromal cell-derived exosomes for enhanced bone healing
Manuscript Source	Invited Manuscript
All Author List	Yue Ding, Fang Lin and Xiao-Ting Liang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81500207 Pyramid Talent Project, China YQ677
Corresponding Author	Xiao-Ting Liang, MD, PhD, Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, No. 150 Jimo Road, Shanghai 200120, China. liangxt@tongji.edu.cn
Key Words	Bone regeneration; Hydrogel; Mesenchymal stem cell-derived exosomes; Inflammation; Angiogenesis
Core Tip	This study introduces a novel hydrogel system embedded with bone marrow stromal cell-derived exosomes that enhances bone regeneration by modulating inflammation and promoting angiogenesis. The dual-role capability of bone marrow stromal cell-derived exosomes in directing cell fate is a significant innovation, demonstrating enhanced angiogenesis and osteogenic differentiation. When validated in a murine fracture model, this approach showed promising potential for clinical application in the treatment of large bone defects. Further detailed investigations are needed to fully understand the therapeutic potential of this innovative strategy.
Citation	Ding Y, Lin F, Liang XT. Innovative hydrogel delivery of bone marrow stromal cell-derived exosomes for enhanced bone healing. World J Stem Cells 2024; In press

Received	2024-06-11 04:46
Peer-Review Started	2024-06-11 04:46
To Make the First Decision
Return for Revision	2024-09-27 10:20
Revised	2024-10-02 14:01
Second Decision	2024-11-29 02:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-29 07:45
Articles in Press	2024-11-29 07:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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