Publication Name	World Journal of Stem Cells
Manuscript ID	98351
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Preliminary study on the preparation of lyophilized acellular nerve scaffold complexes from rabbit sciatic nerves with human umbilical cord mesenchymal stem cells
Manuscript Source	Unsolicited Manuscript
All Author List	Chuang Qian, Shang-Yu Guo, Zheng Xu, Zhi-Qiang Zhang, Hao-Dong Li, Hao Li and Xiong-Sheng Chen
Funding Agency and Grant Number
Corresponding Author	Hao Li, PhD, Department of Neurosurgery, Children’s Hospital of Fudan University & National Children’s Medical Center, No. 399 Wanyuan Road, Minghang District, Shanghai 201102, China. lihao7272@163.com
Key Words	Human umbilical cord mesenchymal stem cells; Peripheral nerve injury; Schwann cells; Acellular nerve scaffolds
Core Tip	The treatment of severe peripheral nerve injuries remains a clinical challenge, particularly in children. Autologous nerve grafts are the standard treatment for these severe neurologic deficits and the scarce number of autologous nerves and the loss of neurosensory function in the donor area are major obstacles, particularly in infants and young children. Allogeneic or xenografts are even more limited by immune rejection. Therefore, there is an urgent need for a peripheral nerve substitute that can bridge the two severed ends of the nerve, guide its axonal growth to avoid the formation of neuroma, and promote and guide the functional regeneration of the peripheral nerve. For patients with neonatal brachial plexus injury, human umbilical cord mesenchymal stem cells (hUC-MSCs) are an effective tool. In this study, we proposed to culture hUC-MSCs as seed cells on suitable decellularized scaffolds.
Citation	Qian C, Guo SY, Xu Z, Zhang ZQ, Li HD, Li H, Chen XS. Preliminary study on the preparation of lyophilized acellular nerve scaffold complexes from rabbit sciatic nerves with human umbilical cord mesenchymal stem cells. World J Stem Cells 2024; In press

Received	2024-08-20 08:16
Peer-Review Started	2024-08-20 08:16
To Make the First Decision
Return for Revision	2024-09-06 10:16
Revised	2024-10-09 13:07
Second Decision	2024-11-05 02:42
Accepted by Journal Editor-in-Chief	2024-11-06 06:09
Accepted by Executive Editor-in-Chief	2024-11-29 08:12
Articles in Press	2024-11-29 08:12
Publication Fee Transferred	2024-12-01 12:47
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ISSN	1948-0210 (online)
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